FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022974589> ?p ?o ?g. }

• W2022974589 endingPage "772" @default.
• W2022974589 startingPage "763" @default.
• W2022974589 abstract "Marijuana and hashish are the illicit drugs most frequently used by human adolescents. Given the continued neurodevelopment throughout adolescence, adolescents may be more vulnerable than adults to certain neural consequences of heavy marijuana use. This study aimed to assess whether an experimental model of adolescent chronic exposure to Δ9-tetrahydrocannabinol (THC), may induce lasting effects on learning and memory. Adolescent rats have been treated with THC or its vehicle from 35 to 45 postnatal days (PND) and left undisturbed until their adulthood (75 PND) when aversive and spatial memory was assessed using the passive avoidance and radial maze tasks. No alteration was found in aversive memory, but in the radial maze THC pretreated animals exhibited a worse performance than vehicles, suggesting a deficit in spatial working memory. To correlate memory impairment to altered neuroplasticity, level of marker proteins was investigated in the hippocampus, the most relevant area mediating spatial memory. A significant decrease in the astroglial marker glial fibrillar acid protein was found as well as in pre- and postsynaptic protein expression (VAMP2, PSD95) and NMDA receptor levels in pretreated rats. To parallel these changes to alteration in dendritic morphology, Golgi-Cox staining was performed in the hippocampal dentate gyrus. Pretreated rats had a significantly lower total dendritic length and number than vehicles, as well as reduced spine density. Our data suggest that THC pretreated rats may establish less synaptic contacts and/or less efficient synaptic connections throughout the hippocampus and this could represent the molecular underpinning of the cognitive deficit induced by adolescent THC treatment. © 2009 Wiley-Liss, Inc." @default.
• W2022974589 created "2016-06-24" @default.
• W2022974589 creator A5028378356 @default.
• W2022974589 creator A5029512095 @default.
• W2022974589 creator A5049982074 @default.
• W2022974589 creator A5053529456 @default.
• W2022974589 creator A5054676996 @default.
• W2022974589 creator A5061203019 @default.
• W2022974589 creator A5063116679 @default.
• W2022974589 creator A5068288757 @default.
• W2022974589 creator A5071401979 @default.
• W2022974589 creator A5072602083 @default.
• W2022974589 creator A5089107666 @default.
• W2022974589 date "2009-08-01" @default.
• W2022974589 modified "2023-09-26" @default.
• W2022974589 title "Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood" @default.
• W2022974589 cites W117237162 @default.
• W2022974589 cites W1481609997 @default.
• W2022974589 cites W1495371383 @default.
• W2022974589 cites W1577989916 @default.
• W2022974589 cites W1624178692 @default.
• W2022974589 cites W1965604886 @default.
• W2022974589 cites W1966407051 @default.
• W2022974589 cites W1970027662 @default.
• W2022974589 cites W1972114740 @default.
• W2022974589 cites W1974776242 @default.
• W2022974589 cites W1976315490 @default.
• W2022974589 cites W1979031928 @default.
• W2022974589 cites W1981985883 @default.
• W2022974589 cites W1982912347 @default.
• W2022974589 cites W1985916296 @default.
• W2022974589 cites W1988488160 @default.
• W2022974589 cites W1988652098 @default.
• W2022974589 cites W1994625799 @default.
• W2022974589 cites W2005270780 @default.
• W2022974589 cites W2007001221 @default.
• W2022974589 cites W2008470260 @default.
• W2022974589 cites W2009035682 @default.
• W2022974589 cites W2017169966 @default.
• W2022974589 cites W2018532397 @default.
• W2022974589 cites W2018710502 @default.
• W2022974589 cites W2018800927 @default.
• W2022974589 cites W2020537971 @default.
• W2022974589 cites W2032743934 @default.
• W2022974589 cites W2033319161 @default.
• W2022974589 cites W2034468530 @default.
• W2022974589 cites W2035881421 @default.
• W2022974589 cites W2037158285 @default.
• W2022974589 cites W2058634132 @default.
• W2022974589 cites W2060968549 @default.
• W2022974589 cites W2062170532 @default.
• W2022974589 cites W2064426755 @default.
• W2022974589 cites W2065560079 @default.
• W2022974589 cites W2065637445 @default.
• W2022974589 cites W2073152512 @default.
• W2022974589 cites W2079681298 @default.
• W2022974589 cites W2082965072 @default.
• W2022974589 cites W2085680244 @default.
• W2022974589 cites W2085884412 @default.
• W2022974589 cites W2088239473 @default.
• W2022974589 cites W2091726345 @default.
• W2022974589 cites W2093077098 @default.
• W2022974589 cites W2096472685 @default.
• W2022974589 cites W2101473364 @default.
• W2022974589 cites W2105549490 @default.
• W2022974589 cites W2107417127 @default.
• W2022974589 cites W2107585091 @default.
• W2022974589 cites W2114413673 @default.
• W2022974589 cites W2115094058 @default.
• W2022974589 cites W2116014415 @default.
• W2022974589 cites W2128752949 @default.
• W2022974589 cites W2132159513 @default.
• W2022974589 cites W2136249808 @default.
• W2022974589 cites W2148908396 @default.
• W2022974589 cites W2151070269 @default.
• W2022974589 cites W2154021054 @default.
• W2022974589 cites W2165995362 @default.
• W2022974589 cites W2176569267 @default.
• W2022974589 cites W4256399101 @default.
• W2022974589 cites W4293872195 @default.
• W2022974589 doi "https://doi.org/10.1002/hipo.20554" @default.
• W2022974589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19156848" @default.
• W2022974589 hasPublicationYear "2009" @default.
• W2022974589 type Work @default.
• W2022974589 sameAs 2022974589 @default.
• W2022974589 citedByCount "245" @default.
• W2022974589 countsByYear W20229745892012 @default.
• W2022974589 countsByYear W20229745892013 @default.
• W2022974589 countsByYear W20229745892014 @default.
• W2022974589 countsByYear W20229745892015 @default.
• W2022974589 countsByYear W20229745892016 @default.
• W2022974589 countsByYear W20229745892017 @default.
• W2022974589 countsByYear W20229745892018 @default.
• W2022974589 countsByYear W20229745892019 @default.
• W2022974589 countsByYear W20229745892020 @default.
• W2022974589 countsByYear W20229745892021 @default.
• W2022974589 countsByYear W20229745892022 @default.
• W2022974589 countsByYear W20229745892023 @default.

• next