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• W2022974923 endingPage "177" @default.
• W2022974923 startingPage "171" @default.
• W2022974923 abstract "Human adipose-derived mesenchymal stem cells (hASCs) are attractive cell source for skin tissue engineering. The aim of this study was to investigate the effects of low-level light therapy (LLLT) on transplanted cluster hASC in a skin wound animal model. The hASCs were cultured in monolayer or clusters. The LLLT, hASCs, hASC clusters, and hASC clusters transplantation with LLLT (cluster + LLLT) were applied to the wound bed in athymic mice. Wound healing was assessed by gross evaluation and by hematoxylin and eosin staining, and elastin van gieson histochemistry. The survival, differentiation, and secretion of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF), and hepatocyte growth factor (HGF) of the cluster ASC were evaluated by immunohistochemistry and Western blotting. The cluster + LLLT group enhanced the wound healing, including neovascularization and regeneration of skin appendages, compared with the cluster group. The secretion of growth factors was stimulated in the cluster + LLLT group compared with the ASCs and cluster group. These data suggest that LLLT is an effective biostimulator of cluster hASCs in wound healing that enhances the survival of hASCs and stimulates the secretion of growth factors in the wound bed." @default.
• W2022974923 created "2016-06-24" @default.
• W2022974923 creator A5029016961 @default.
• W2022974923 creator A5045468765 @default.
• W2022974923 creator A5080195458 @default.
• W2022974923 date "2015-07-01" @default.
• W2022974923 modified "2023-10-17" @default.
• W2022974923 title "Adipose-derived stromal cell cluster with light therapy enhance angiogenesis and skin wound healing in mice" @default.
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• W2022974923 doi "https://doi.org/10.1016/j.bbrc.2015.04.059" @default.
• W2022974923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25911320" @default.
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