FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W20229775> ?p ?o ?g. }

• W20229775 endingPage "73" @default.
• W20229775 startingPage "67" @default.
• W20229775 abstract "The effects of cholecystokinin (CCK) receptor antagonist Loxiglumide (CR 1505) on pancreatic exocrine secretion and growth stimulated by chronic bile-pancreatic juice diversion to the ileum were studied in conscious rats. Pancreatic secretion was measured each day at 0900 h for 7 d. Pancreatic flow and protein output were significantly increased 24 h after bile-pancreatic juice diversion. Protein output increased each successive day, reaching maximal values of 3.6-fold above basal by the 6th and 7th d of chronic bilepancreatic juice diversion. Fluid output reached maximal values of approx 3.5-fold above basal by the 3rd d of chronic bile-pancreatic juice diversion. Plasma CCK increased threefold above basal levels after 24 h of bile-pancreatic juice diversion and remained three- to fourfold above basal. Intragastric bolus infusion of CR 1505 (50 mg/kg) on the 7th d of chronic bile-pancreatic juice diversion inhibited pancreatic protein and fluid secretion by 80 and 75%, respectively, 60 min after administration and by 52 and 71%, respectively, 5 h later. Pancreatic wet wt after 7 d of chronic bile-pancreatic juice diversion was significantly increased by 56%, and this was completely suppressed by 50 mg/kg of CR 1505 given intragastrically every 12 h. These rests indicate that the rat with chronic bile-pancreatic juice diversion is a useful model to examine both potency and duration of the action of CCK receptor antagonists and show that CR 1505 inhibits pancreatic exocrine secretion and growth induced by endogenous CCK." @default.
• W20229775 created "2016-06-24" @default.
• W20229775 creator A5049633500 @default.
• W20229775 creator A5050960477 @default.
• W20229775 creator A5061524107 @default.
• W20229775 creator A5089372173 @default.
• W20229775 date "1992-04-01" @default.
• W20229775 modified "2023-09-25" @default.
• W20229775 title "Inhibitory effects of the cholecystokinin antagonist loxiglumide on pancreatic exocrine secretion and pancreatic growth in conscious rats" @default.
• W20229775 cites W1246997541 @default.
• W20229775 cites W129532530 @default.
• W20229775 cites W1504176527 @default.
• W20229775 cites W1527613114 @default.
• W20229775 cites W1641631376 @default.
• W20229775 cites W1646340036 @default.
• W20229775 cites W1792429257 @default.
• W20229775 cites W1800048765 @default.
• W20229775 cites W1825291712 @default.
• W20229775 cites W1842060488 @default.
• W20229775 cites W1965260950 @default.
• W20229775 cites W1967318598 @default.
• W20229775 cites W1975509755 @default.
• W20229775 cites W2014685085 @default.
• W20229775 cites W2015046754 @default.
• W20229775 cites W2026851211 @default.
• W20229775 cites W2033724612 @default.
• W20229775 cites W2038552915 @default.
• W20229775 cites W2051171095 @default.
• W20229775 cites W2077464002 @default.
• W20229775 cites W2093099606 @default.
• W20229775 cites W2200515367 @default.
• W20229775 cites W2324354297 @default.
• W20229775 cites W2327529589 @default.
• W20229775 cites W2329568258 @default.
• W20229775 cites W2333999038 @default.
• W20229775 cites W2403233036 @default.
• W20229775 cites W2403350102 @default.
• W20229775 cites W2411734637 @default.
• W20229775 cites W2418154393 @default.
• W20229775 cites W2428555817 @default.
• W20229775 cites W2441477060 @default.
• W20229775 cites W2468682133 @default.
• W20229775 cites W2475360713 @default.
• W20229775 cites W3109638071 @default.
• W20229775 cites W6280767 @default.
• W20229775 cites W2419875074 @default.
• W20229775 doi "https://doi.org/10.1007/bf02925977" @default.
• W20229775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1607730" @default.
• W20229775 hasPublicationYear "1992" @default.
• W20229775 type Work @default.
• W20229775 sameAs 20229775 @default.
• W20229775 citedByCount "5" @default.
• W20229775 crossrefType "journal-article" @default.
• W20229775 hasAuthorship W20229775A5049633500 @default.
• W20229775 hasAuthorship W20229775A5050960477 @default.
• W20229775 hasAuthorship W20229775A5061524107 @default.
• W20229775 hasAuthorship W20229775A5089372173 @default.
• W20229775 hasConcept C126322002 @default.
• W20229775 hasConcept C134018914 @default.
• W20229775 hasConcept C170493617 @default.
• W20229775 hasConcept C185592680 @default.
• W20229775 hasConcept C2776885963 @default.
• W20229775 hasConcept C2777593968 @default.
• W20229775 hasConcept C2777951760 @default.
• W20229775 hasConcept C2778024521 @default.
• W20229775 hasConcept C2778764654 @default.
• W20229775 hasConcept C2779306644 @default.
• W20229775 hasConcept C32110497 @default.
• W20229775 hasConcept C56191518 @default.
• W20229775 hasConcept C57380142 @default.
• W20229775 hasConcept C71924100 @default.
• W20229775 hasConceptScore W20229775C126322002 @default.
• W20229775 hasConceptScore W20229775C134018914 @default.
• W20229775 hasConceptScore W20229775C170493617 @default.
• W20229775 hasConceptScore W20229775C185592680 @default.
• W20229775 hasConceptScore W20229775C2776885963 @default.
• W20229775 hasConceptScore W20229775C2777593968 @default.
• W20229775 hasConceptScore W20229775C2777951760 @default.
• W20229775 hasConceptScore W20229775C2778024521 @default.
• W20229775 hasConceptScore W20229775C2778764654 @default.
• W20229775 hasConceptScore W20229775C2779306644 @default.
• W20229775 hasConceptScore W20229775C32110497 @default.
• W20229775 hasConceptScore W20229775C56191518 @default.
• W20229775 hasConceptScore W20229775C57380142 @default.
• W20229775 hasConceptScore W20229775C71924100 @default.
• W20229775 hasIssue "2" @default.
• W20229775 hasLocation W202297751 @default.
• W20229775 hasLocation W202297752 @default.
• W20229775 hasOpenAccess W20229775 @default.
• W20229775 hasPrimaryLocation W202297751 @default.
• W20229775 hasRelatedWork W1982594208 @default.
• W20229775 hasRelatedWork W1993973335 @default.
• W20229775 hasRelatedWork W2034906614 @default.
• W20229775 hasRelatedWork W2040601647 @default.
• W20229775 hasRelatedWork W2063662253 @default.
• W20229775 hasRelatedWork W2117395917 @default.
• W20229775 hasRelatedWork W2167719373 @default.
• W20229775 hasRelatedWork W2409944325 @default.

• next