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- W2022981145 abstract "The effect of 7-week forced oral nicotine exposure on acquisition of intravenous nicotine self-administration, nicotine place conditioning, and nicotine preference was studied in mice. The nicotine solution was given in stepwise increased concentrations as the sole source of liquid for 7 weeks. Nicotine exposed animals self-administered nicotine intravenously at lower unit dose than nicotine-naïve ones, indicating that the forced 7-week nicotine exposure, followed by 7-day withdrawal, had rendered them more sensitive to nicotine's reinforcing effects. At the dose of 0.5 mg/kg, nicotine induced conditioned place preference both in drug-naïve and nicotine exposed mice, but the 0.3 mg/kg dose of nicotine failed to do so. The forced nicotine pre-exposure did not alter the nicotine preference in the 2-bottle free-choice paradigm. In conclusion, these results suggest that nicotine pre-exposure enhances the reinforcing effects of acutely administered nicotine only in the intravenous self-administration model." @default.
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- W2022981145 date "2008-09-01" @default.
- W2022981145 modified "2023-09-22" @default.
- W2022981145 title "Effect of forced chronic oral nicotine exposure on intravenous self-administration and rewarding properties of acute nicotine" @default.
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- W2022981145 doi "https://doi.org/10.1016/j.ejphar.2008.06.081" @default.
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