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• W2022982030 endingPage "1156" @default.
• W2022982030 startingPage "1149" @default.
• W2022982030 abstract "Endothelin-1, initially identified as potent vasoconstrictor secreted by vascular endothelial cells, was subsequently found to have many effects on both vascular and nonvascular tissues. We have identified from a human placenta cDNA library a clone (cDNA-2) which corresponds to a novel 5'-extended preproendothelin 1 (preproET-1) mRNA. Comparison with the known preproET-1 mRNA (cDNA-1), showed that the two molecules share the same coding sequence but differ in the 5'-untranslated region. Interestingly, cDNA-2 extends upstream of promoter regions previously shown to be essential for full preproET-1 expression. Primer extension and PCR analysis of human placenta RNA demonstrated the presence of additional transcription initiation sites located upstream of the previously identified preproET-1 CAP site. Moreover, the two mRNAs show different pattern of expression. To elucidate the mechanisms controlling the production of alternative transcripts we transfected COS-1 cells with a series of preproET-1 promoter deletion mutants. This analysis revealed that the human preproET-1 gene can be transcribed from a proximal and a distal promoter element which has hitherto been undetected. In addition, we demonstrate the presence of a region in the down-epithelial specific expression." @default.
• W2022982030 created "2016-06-24" @default.
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• W2022982030 date "1993-03-01" @default.
• W2022982030 modified "2023-09-25" @default.
• W2022982030 title "Two preproendothelin 1 mRNAs transcribed by alternative promoters." @default.
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• W2022982030 doi "https://doi.org/10.1172/jci116274" @default.
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