Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022982231> ?p ?o ?g. }
- W2022982231 endingPage "6182" @default.
- W2022982231 startingPage "6172" @default.
- W2022982231 abstract "Abstract The mechanisms by which innate immune signals regulate alloimmune responses remain poorly understood. In the present study, we show by intravital 2-photon microscopy direct interactions between graft-infiltrating neutrophils and donor CD11c+ dendritic cells (DCs) within orthotopic lung allografts immediately after reperfusion. Neutrophils isolated from the airways of lung transplantation recipients stimulate donor DCs in a contact-dependent fashion to augment their production of IL-12 and expand alloantigen-specific IFN-γ+ T cells. DC IL-12 expression is largely regulated by degranulation and induced by TNF-α associated with the neutrophil plasma membrane. Extended cold ischemic graft storage enhances G-CSF–mediated granulopoiesis and neutrophil graft infiltration, resulting in exacerbation of ischemia-reperfusion injury after lung transplantation. Ischemia reperfusion injury prevents immunosuppression-mediated acceptance of mouse lung allografts unless G-CSF–mediated granulopoiesis is inhibited. Our findings identify granulopoiesis-mediated augmentation of alloimmunity as a novel link between innate and adaptive immune responses after organ transplantation." @default.
- W2022982231 created "2016-06-24" @default.
- W2022982231 creator A5001045635 @default.
- W2022982231 creator A5004862917 @default.
- W2022982231 creator A5005027392 @default.
- W2022982231 creator A5008223387 @default.
- W2022982231 creator A5016660645 @default.
- W2022982231 creator A5029413232 @default.
- W2022982231 creator A5033149046 @default.
- W2022982231 creator A5038761572 @default.
- W2022982231 creator A5055841327 @default.
- W2022982231 creator A5072091369 @default.
- W2022982231 creator A5073923248 @default.
- W2022982231 creator A5080121245 @default.
- W2022982231 creator A5084017688 @default.
- W2022982231 creator A5087757869 @default.
- W2022982231 date "2011-12-01" @default.
- W2022982231 modified "2023-10-17" @default.
- W2022982231 title "Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance" @default.
- W2022982231 cites W1511403203 @default.
- W2022982231 cites W1570007714 @default.
- W2022982231 cites W1657764750 @default.
- W2022982231 cites W1822335577 @default.
- W2022982231 cites W1842423069 @default.
- W2022982231 cites W1907480148 @default.
- W2022982231 cites W1942966726 @default.
- W2022982231 cites W1965471441 @default.
- W2022982231 cites W1972590847 @default.
- W2022982231 cites W1983688860 @default.
- W2022982231 cites W1986957385 @default.
- W2022982231 cites W1987598864 @default.
- W2022982231 cites W1990526178 @default.
- W2022982231 cites W1995048629 @default.
- W2022982231 cites W1996512088 @default.
- W2022982231 cites W1997103581 @default.
- W2022982231 cites W2002323163 @default.
- W2022982231 cites W2003687800 @default.
- W2022982231 cites W2005631373 @default.
- W2022982231 cites W2005829070 @default.
- W2022982231 cites W2006115376 @default.
- W2022982231 cites W2006323392 @default.
- W2022982231 cites W2008579121 @default.
- W2022982231 cites W2009454655 @default.
- W2022982231 cites W2014745588 @default.
- W2022982231 cites W2018406955 @default.
- W2022982231 cites W2022443457 @default.
- W2022982231 cites W2024814259 @default.
- W2022982231 cites W2031078224 @default.
- W2022982231 cites W2033884349 @default.
- W2022982231 cites W2038796948 @default.
- W2022982231 cites W2040937550 @default.
- W2022982231 cites W2047569382 @default.
- W2022982231 cites W2059238586 @default.
- W2022982231 cites W2061341693 @default.
- W2022982231 cites W2066506357 @default.
- W2022982231 cites W2071508682 @default.
- W2022982231 cites W2074881372 @default.
- W2022982231 cites W2081217845 @default.
- W2022982231 cites W2096204372 @default.
- W2022982231 cites W2108256385 @default.
- W2022982231 cites W2123037720 @default.
- W2022982231 cites W2123076394 @default.
- W2022982231 cites W2125139598 @default.
- W2022982231 cites W2130896660 @default.
- W2022982231 cites W2134709146 @default.
- W2022982231 cites W2136241895 @default.
- W2022982231 cites W2136386024 @default.
- W2022982231 cites W2142213477 @default.
- W2022982231 cites W2142511555 @default.
- W2022982231 cites W2150573258 @default.
- W2022982231 cites W2159913536 @default.
- W2022982231 cites W2164999176 @default.
- W2022982231 cites W2165056939 @default.
- W2022982231 cites W2165305878 @default.
- W2022982231 cites W2166433840 @default.
- W2022982231 cites W324624459 @default.
- W2022982231 cites W4243641777 @default.
- W2022982231 doi "https://doi.org/10.1182/blood-2011-04-347823" @default.
- W2022982231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3234670" @default.
- W2022982231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21972291" @default.
- W2022982231 hasPublicationYear "2011" @default.
- W2022982231 type Work @default.
- W2022982231 sameAs 2022982231 @default.
- W2022982231 citedByCount "92" @default.
- W2022982231 countsByYear W20229822312012 @default.
- W2022982231 countsByYear W20229822312013 @default.
- W2022982231 countsByYear W20229822312014 @default.
- W2022982231 countsByYear W20229822312015 @default.
- W2022982231 countsByYear W20229822312016 @default.
- W2022982231 countsByYear W20229822312017 @default.
- W2022982231 countsByYear W20229822312018 @default.
- W2022982231 countsByYear W20229822312019 @default.
- W2022982231 countsByYear W20229822312020 @default.
- W2022982231 countsByYear W20229822312021 @default.
- W2022982231 countsByYear W20229822312022 @default.
- W2022982231 countsByYear W20229822312023 @default.
- W2022982231 crossrefType "journal-article" @default.
- W2022982231 hasAuthorship W2022982231A5001045635 @default.