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- W2022983967 abstract "Malignant hypertension remains one of the life-threatening complications of blood pressure elevation. It is a clinico-pathological syndrome of severe blood pressure elevation combined with malignant vascular injury. This is a characteristic form of vascular damage, with two elements: fibrinoid necrosis and endarteritis proliferans. Although the morphology of these has been well described, the molecular events are not fully understood. This review summarizes the evidence from transgenic animals for a role for the activation of a local paracrine renin–angiotensin system in the pathogenesis of malignant vascular injury. These animal models provide pathological, pharmacological, and genetic evidence supporting the hypothesis that intra-renal generation of angiotensin 2 and exposure of the microcirculation to elevated blood pressure co-operate in causing tissue damage in malignant hypertension. Copyright © 2000 John Wiley & Sons, Ltd." @default.
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- W2022983967 date "2000-01-01" @default.
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- W2022983967 title "Malignant hypertension - the role of the paracrine renin-angiotensin system" @default.
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- W2022983967 doi "https://doi.org/10.1002/1096-9896(2000)9999:9999<::aid-path674>3.0.co;2-q" @default.
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