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- W202298465 abstract "The in situ hybridization technique was used to investigate the expression of the human cellular oncogenes, c-myc, c-myb and c-fes, simultaneously on different cell populations: normal resting and PHA stimulated T lymphocytes, leukemic resting and LPS stimulated B lymphocytes, AML, CML and IM cells. The probes used were the clones pCM 41.5 and pCM 41.3 corresponding to the 5’ and 3’ terminal of c-myc, the clone F8 corresponding to the 3’ terminal of c-myb and the clone p 26 corresponding to the 5’ terminal of c-fes, Snyder-Theilen strain. In all myeloid cell populations c-myc, c-myb and c-fes expression was detected, but while c-myc and c-myb were present at a higher level in immature cells and decreased during myeloid maturation, c-fes markedly increased in more mature elements. The expression of c-fes was not detected in normal and leukemic lymphoid cells, while c-myc and c-myb, detectable at a very low degree in resting lymphocytes, drastically increased in mitogen stimulated normal and leukemic cells." @default.
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- W202298465 date "1985-01-01" @default.
- W202298465 modified "2023-09-23" @default.
- W202298465 title "Detection of c-myc, c-myb and c-fes Oncogene Transcripts in Human Myeloid and Lymphoid Normal and Leukemic Cells by in Situ Hybridization" @default.
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- W202298465 doi "https://doi.org/10.1007/978-1-4612-5008-1_49" @default.
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