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- W2022984703 abstract "A synthetic ligand for the protein FKBP12 was covalently linked to a peptide ligand (pYEEI) for the Fyn SH2 protein to create a bifunctional molecule called SLFpYEEI. This bifunctional molecule can simultaneously bind both proteins to form a trimeric complex. When SLFpYEEI is precomplexed with FKBP12, the peptide ligand binds 6-fold more weakly to the Fyn SH2 domain than SLFpYEEI alone. Isotope-edited NMR spectroscopy was used to investigate the molecular basis for the observed reduction in affinity. The results suggest that interactions between the pYEEI peptide and FKBP12 may play a significant role in diminishing the affinity of SLFpYEEI for the Fyn SH2 domain." @default.
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- W2022984703 date "2000-11-15" @default.
- W2022984703 modified "2023-09-23" @default.
- W2022984703 title "Mechanistic Studies of Affinity Modulation" @default.
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- W2022984703 doi "https://doi.org/10.1021/ja002991m" @default.
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