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• W2022987064 endingPage "5512" @default.
• W2022987064 startingPage "5503" @default.
• W2022987064 abstract "MicroRNAs (miRNAs) are key mediators of post-transcriptional gene regulation. The miRNA precursors are processed by the endonucleases Drosha and Dicer into a duplex, bound to an Argonaute protein and unwound into two single-stranded miRNAs. Although alternative ways to generate miRNAs have been discovered, e.g. pre-miRNA cleavage by Ago2 or cleavage products of snoRNAs or tRNAs, all known pathways converge on a double-stranded RNA duplex. Exogenous single-stranded siRNAs (ss-siRNAs) can elicit an effective RNA interference reaction; recent studies have identified chemical modifications increasing their stability and activity. Here, we provide first evidence that endogenous, unmodified, single-stranded RNA sequences are generated from single-stranded loop regions of human pre-miRNA hairpins, the so called loop-miRs. Luciferase assays and immunoprecipitation validate loop-miR activity and incorporation into RNA-induced silencing complexes. This study identifies endogenous miRNAs that are generated from single-stranded regions; hence, it provides evidence that precursor-miRNAs can give rise to three distinct endogenous miRNAs: the guide strand, the passenger strand and the loop-miR." @default.
• W2022987064 created "2016-06-24" @default.
• W2022987064 creator A5037234316 @default.
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• W2022987064 creator A5067961756 @default.
• W2022987064 creator A5076621115 @default.
• W2022987064 date "2013-04-10" @default.
• W2022987064 modified "2023-10-14" @default.
• W2022987064 title "Loop-miRs: active microRNAs generated from single-stranded loop regions" @default.
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• W2022987064 doi "https://doi.org/10.1093/nar/gkt251" @default.
• W2022987064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3664828" @default.
• W2022987064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23580554" @default.
• W2022987064 hasPublicationYear "2013" @default.
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