FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022987546> ?p ?o ?g. }

• W2022987546 endingPage "850" @default.
• W2022987546 startingPage "842" @default.
• W2022987546 abstract "Accumulating evidence suggests that grape seed and wine polyphenol extracts possess a diverse array of actions and may be beneficial in the prevention of inflammatory-mediated disease such as cardiovascular disease and cancer. This study aimed to determine whether the reported pleiotropic effects of several polyphenolic extracts from grape seed products or red wine would also include inhibition of cholesterol uptake and cell proliferation, and inhibit a known specific target of the inflammatory process, that is, 5-lipoxygenase (5-LOX). Incubation of HT29, Caco2, HepG2, or HuTu80 cells in a medium containing [(3)H]cholesterol in the presence of a grape seed extract (GSE) or red wine polyphenolic compounds (RWPCs) inhibited [(3)H]cholesterol uptake by up to 66% (which appeared maximal). The estimated IC(50) values were 60 and 83 microg/mL for RWPC and GSE, respectively. Similar cholesterol uptake inhibitory effects were observed using the fluorescent cholesterol analogue NBD cholesterol. The inhibition of cholesterol uptake was independent of the sample's (GSE and RWPC) potent antioxidative capacity. Red wine polyphenolic compound and GSE dose dependently inhibited HT29 colon adenocarcinoma cell proliferation, which was accompanied by an increase in apoptosis. In addition, RWPC and GSE inhibited 5-LOX activity with the IC(50) values being 35 and 13 microg/mL, respectively. Two of 3 other GSEs tested also significantly inhibited 5-LOX activity. Inhibition of cholesterol uptake and proinflammatory 5-LOX activity may be beneficial in preventing the development of chronic degenerative diseases such as cardiovascular disease and cancer." @default.
• W2022987546 created "2016-06-24" @default.
• W2022987546 creator A5038480990 @default.
• W2022987546 creator A5087320270 @default.
• W2022987546 date "2008-12-01" @default.
• W2022987546 modified "2023-09-27" @default.
• W2022987546 title "Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity" @default.
• W2022987546 cites W1554294005 @default.
• W2022987546 cites W1569214109 @default.
• W2022987546 cites W1956882878 @default.
• W2022987546 cites W1964382263 @default.
• W2022987546 cites W1968547511 @default.
• W2022987546 cites W1970075362 @default.
• W2022987546 cites W1983237356 @default.
• W2022987546 cites W1984358846 @default.
• W2022987546 cites W1994540520 @default.
• W2022987546 cites W1998936301 @default.
• W2022987546 cites W2000130157 @default.
• W2022987546 cites W2001167649 @default.
• W2022987546 cites W2007340372 @default.
• W2022987546 cites W2018967387 @default.
• W2022987546 cites W2024566221 @default.
• W2022987546 cites W2034104198 @default.
• W2022987546 cites W2034945330 @default.
• W2022987546 cites W2035556394 @default.
• W2022987546 cites W2039504794 @default.
• W2022987546 cites W2047092377 @default.
• W2022987546 cites W2052068344 @default.
• W2022987546 cites W2053232746 @default.
• W2022987546 cites W2067701179 @default.
• W2022987546 cites W2077146601 @default.
• W2022987546 cites W2080776250 @default.
• W2022987546 cites W2088861887 @default.
• W2022987546 cites W2090894363 @default.
• W2022987546 cites W2093924538 @default.
• W2022987546 cites W2096639977 @default.
• W2022987546 cites W2109663925 @default.
• W2022987546 cites W2110596984 @default.
• W2022987546 cites W2111188390 @default.
• W2022987546 cites W2111649506 @default.
• W2022987546 cites W2112247589 @default.
• W2022987546 cites W2117877053 @default.
• W2022987546 cites W2129937483 @default.
• W2022987546 cites W2132634377 @default.
• W2022987546 cites W2140093671 @default.
• W2022987546 cites W2140928002 @default.
• W2022987546 cites W2140957970 @default.
• W2022987546 cites W2141422587 @default.
• W2022987546 cites W2148030627 @default.
• W2022987546 cites W2151089147 @default.
• W2022987546 cites W2161585328 @default.
• W2022987546 cites W2184912837 @default.
• W2022987546 cites W2323106749 @default.
• W2022987546 doi "https://doi.org/10.1016/j.nutres.2008.09.001" @default.
• W2022987546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19083497" @default.
• W2022987546 hasPublicationYear "2008" @default.
• W2022987546 type Work @default.
• W2022987546 sameAs 2022987546 @default.
• W2022987546 citedByCount "100" @default.
• W2022987546 countsByYear W20229875462012 @default.
• W2022987546 countsByYear W20229875462013 @default.
• W2022987546 countsByYear W20229875462014 @default.
• W2022987546 countsByYear W20229875462015 @default.
• W2022987546 countsByYear W20229875462016 @default.
• W2022987546 countsByYear W20229875462017 @default.
• W2022987546 countsByYear W20229875462018 @default.
• W2022987546 countsByYear W20229875462019 @default.
• W2022987546 countsByYear W20229875462020 @default.
• W2022987546 countsByYear W20229875462021 @default.
• W2022987546 countsByYear W20229875462022 @default.
• W2022987546 countsByYear W20229875462023 @default.
• W2022987546 crossrefType "journal-article" @default.
• W2022987546 hasAuthorship W2022987546A5038480990 @default.
• W2022987546 hasAuthorship W2022987546A5087320270 @default.
• W2022987546 hasConcept C142724271 @default.
• W2022987546 hasConcept C181199279 @default.
• W2022987546 hasConcept C185592680 @default.
• W2022987546 hasConcept C204787440 @default.
• W2022987546 hasConcept C2776971262 @default.
• W2022987546 hasConcept C2778004101 @default.
• W2022987546 hasConcept C2778163477 @default.
• W2022987546 hasConcept C2780857362 @default.
• W2022987546 hasConcept C31903555 @default.
• W2022987546 hasConcept C55493867 @default.
• W2022987546 hasConcept C55952523 @default.
• W2022987546 hasConcept C62112901 @default.
• W2022987546 hasConcept C70899900 @default.
• W2022987546 hasConcept C71924100 @default.
• W2022987546 hasConcept C86803240 @default.
• W2022987546 hasConcept C98274493 @default.
• W2022987546 hasConceptScore W2022987546C142724271 @default.
• W2022987546 hasConceptScore W2022987546C181199279 @default.
• W2022987546 hasConceptScore W2022987546C185592680 @default.
• W2022987546 hasConceptScore W2022987546C204787440 @default.
• W2022987546 hasConceptScore W2022987546C2776971262 @default.
• W2022987546 hasConceptScore W2022987546C2778004101 @default.
• W2022987546 hasConceptScore W2022987546C2778163477 @default.
• W2022987546 hasConceptScore W2022987546C2780857362 @default.

• next