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- W2022987580 abstract "“Parallel-Series” Biphasic Waveform. Introduction: A biphasic defibrillation waveform can achieve a large second phase leading-edge voltage by a “parallel-series” switching system. Recently, such a system using two 30-μF capacitances demonstrated better defibrillation threshold than standard waveforms available in current implantable devices. However, the optimized tilt of such a “parallel-series” system had not been defined. Methods and Results: Defibrillation thresholds were evaluated for five different biphasic “parallel-series” waveforms (60/15 μF) and a biphasic “parallel-parallel” waveform (60/60 μF) in 12 anesthetized pigs. The five “parallel-series” waveforms had first phase tilts of 40%, 50%, 60%, 70%, and 80% with second phase pulse width of 3 msec. The “parallel-parallel” waveform had first phase tilt of 50% with second phase pulse width of 3 msec. The defibrillation lead system comprised a left pectoral “hot can” electrode (cathode) and a right ventricular lead (anode). The stored energy at defibrillation threshold of the “parallel-series” waveform with first phase tilts of 40%, 50%, 60%, 70%, and 80% was 7.0 ± 2.1, 6.1 ± 2.8, 6.8 ± 2.8, 7.2 ± 2.9. and 8.4 ± 3.1 J, respectively. The stored energy of the “parallel-series” waveform with a 50% first phase tilt was 16% less than the nonswitching “parallel-parallel” waveform (7.3 ± 2.8 J, P = 0.006). Conclusions: A first phase tilt of 50% maximized defibrillation efficacy of biphasic waveforms implemented with a “parallel-series” switching system. This optimized “parallel-series” waveform was more efficient than the comparable “parallel-parallel” biphasic waveform having the same first phase capacitance and tilt." @default.
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- W2022987580 date "1997-06-01" @default.
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- W2022987580 title "Optimized First Phase Tilt in Parallel-Series Biphasic Waveform" @default.
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- W2022987580 doi "https://doi.org/10.1111/j.1540-8167.1997.tb01828.x" @default.
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