Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022987731> ?p ?o ?g. }
- W2022987731 abstract "Abstract Background In normal adult skeletal muscle, cell turnover is very slow. However, after an acute lesion or in chronic pathological conditions, such as primary myopathies, muscle stem cells, called satellite cells, are induced to proliferate, then withdraw definitively from the cell cycle and fuse to reconstitute functional myofibers. Results We show that Maged1 is expressed at very low levels in normal adult muscle but is strongly induced after injury, during the early phase of myoblast differentiation. By comparing in vitro differentiation of myoblasts derived from wild-type or Maged1 knockout mice, we observed that Maged1 deficiency results in reduced levels of p21 CIP1/WAF1 , defective cell cycle exit and impaired myotube maturation. In vivo, this defect results in delayed regeneration of injured muscle. Conclusions These data demonstrate for the first time that Maged1 is an important factor required for proper skeletal myoblast differentiation and muscle healing." @default.
- W2022987731 created "2016-06-24" @default.
- W2022987731 creator A5018449456 @default.
- W2022987731 creator A5019368250 @default.
- W2022987731 creator A5026281611 @default.
- W2022987731 creator A5067728030 @default.
- W2022987731 creator A5088233362 @default.
- W2022987731 date "2010-07-20" @default.
- W2022987731 modified "2023-10-18" @default.
- W2022987731 title "Maged1, a new regulator of skeletal myogenic differentiation and muscle regeneration" @default.
- W2022987731 cites W1971179019 @default.
- W2022987731 cites W1974092339 @default.
- W2022987731 cites W1974725392 @default.
- W2022987731 cites W1977614198 @default.
- W2022987731 cites W1978668631 @default.
- W2022987731 cites W1982507101 @default.
- W2022987731 cites W1991745061 @default.
- W2022987731 cites W2010922065 @default.
- W2022987731 cites W2018258194 @default.
- W2022987731 cites W2019673480 @default.
- W2022987731 cites W2028817220 @default.
- W2022987731 cites W2034514059 @default.
- W2022987731 cites W2036708294 @default.
- W2022987731 cites W2041491055 @default.
- W2022987731 cites W2052651806 @default.
- W2022987731 cites W2053278893 @default.
- W2022987731 cites W2053520824 @default.
- W2022987731 cites W2053648381 @default.
- W2022987731 cites W2053881507 @default.
- W2022987731 cites W2056818201 @default.
- W2022987731 cites W2061183445 @default.
- W2022987731 cites W2063156985 @default.
- W2022987731 cites W2064345416 @default.
- W2022987731 cites W2064726837 @default.
- W2022987731 cites W2066121149 @default.
- W2022987731 cites W2071923788 @default.
- W2022987731 cites W2078709292 @default.
- W2022987731 cites W2082670705 @default.
- W2022987731 cites W2083405476 @default.
- W2022987731 cites W2096739766 @default.
- W2022987731 cites W2103274097 @default.
- W2022987731 cites W2115478217 @default.
- W2022987731 cites W2121619780 @default.
- W2022987731 cites W2124139409 @default.
- W2022987731 cites W2124429289 @default.
- W2022987731 cites W2137742613 @default.
- W2022987731 cites W2139162336 @default.
- W2022987731 cites W2149539664 @default.
- W2022987731 cites W2153781529 @default.
- W2022987731 cites W2153996323 @default.
- W2022987731 cites W2154423739 @default.
- W2022987731 cites W2167636834 @default.
- W2022987731 doi "https://doi.org/10.1186/1471-2121-11-57" @default.
- W2022987731 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2912822" @default.
- W2022987731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20646279" @default.
- W2022987731 hasPublicationYear "2010" @default.
- W2022987731 type Work @default.
- W2022987731 sameAs 2022987731 @default.
- W2022987731 citedByCount "16" @default.
- W2022987731 countsByYear W20229877312012 @default.
- W2022987731 countsByYear W20229877312014 @default.
- W2022987731 countsByYear W20229877312015 @default.
- W2022987731 countsByYear W20229877312016 @default.
- W2022987731 countsByYear W20229877312020 @default.
- W2022987731 countsByYear W20229877312022 @default.
- W2022987731 crossrefType "journal-article" @default.
- W2022987731 hasAuthorship W2022987731A5018449456 @default.
- W2022987731 hasAuthorship W2022987731A5019368250 @default.
- W2022987731 hasAuthorship W2022987731A5026281611 @default.
- W2022987731 hasAuthorship W2022987731A5067728030 @default.
- W2022987731 hasAuthorship W2022987731A5088233362 @default.
- W2022987731 hasBestOaLocation W20229877311 @default.
- W2022987731 hasConcept C104317684 @default.
- W2022987731 hasConcept C105702510 @default.
- W2022987731 hasConcept C148738053 @default.
- W2022987731 hasConcept C1491633281 @default.
- W2022987731 hasConcept C171056886 @default.
- W2022987731 hasConcept C207200792 @default.
- W2022987731 hasConcept C2779959927 @default.
- W2022987731 hasConcept C28328180 @default.
- W2022987731 hasConcept C29537977 @default.
- W2022987731 hasConcept C54355233 @default.
- W2022987731 hasConcept C6929976 @default.
- W2022987731 hasConcept C86803240 @default.
- W2022987731 hasConcept C95444343 @default.
- W2022987731 hasConceptScore W2022987731C104317684 @default.
- W2022987731 hasConceptScore W2022987731C105702510 @default.
- W2022987731 hasConceptScore W2022987731C148738053 @default.
- W2022987731 hasConceptScore W2022987731C1491633281 @default.
- W2022987731 hasConceptScore W2022987731C171056886 @default.
- W2022987731 hasConceptScore W2022987731C207200792 @default.
- W2022987731 hasConceptScore W2022987731C2779959927 @default.
- W2022987731 hasConceptScore W2022987731C28328180 @default.
- W2022987731 hasConceptScore W2022987731C29537977 @default.
- W2022987731 hasConceptScore W2022987731C54355233 @default.
- W2022987731 hasConceptScore W2022987731C6929976 @default.
- W2022987731 hasConceptScore W2022987731C86803240 @default.
- W2022987731 hasConceptScore W2022987731C95444343 @default.
- W2022987731 hasIssue "1" @default.
- W2022987731 hasLocation W20229877311 @default.