FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022989013> ?p ?o ?g. }

• W2022989013 endingPage "888" @default.
• W2022989013 startingPage "881" @default.
• W2022989013 abstract "Monoclonal antibody—drug conjugates were applied as a clinical trial for patients who, based on the experimental study, had colorectal cancer. Monoclonal antibody A7, from a mouse splenocyte immunized against human colon cancer, was used as a drug carrier for colon cancer. The anti-cancer drugs mitomycin C (MMC) and neocarzinostatin (NCS) were bound covalently to A7 to form the conjugates A7-MMC and A7–NCS. The in vitro cytotoxic effects of the conjugates on SW1116 cells were stronger than those on free MMC or NCS. The conjugate A7–NCS, when administered to nude mice, brought about the highest NCS tumor concentration, whereas normal immunoglobulin G (IgG)—NCS distributed evenly in all tissues. The conjugates showed a strong antitumor effect on colon cancer transplanted into nude mice. Forty-one patients with colorectal cancer, including ten patients with postoperative metastasis, were given A7–NCS. The immunoperoxidase and drug concentration studies of the resected specimens showed that NCS was localized specifically in cancer. Patients receiving the conjugate did not experience serious adverse effects. Of the eight patients with postoperative liver metastasis, three showed evidence of tumor reduction on computed tomography (CT) scan and three claimed pain relief. The conjugate did not benefit patients with multiple lung metastasis or peritoneal metastasis." @default.
• W2022989013 created "2016-06-24" @default.
• W2022989013 creator A5000369038 @default.
• W2022989013 creator A5012278399 @default.
• W2022989013 creator A5015752932 @default.
• W2022989013 creator A5016529985 @default.
• W2022989013 creator A5023526632 @default.
• W2022989013 creator A5044318331 @default.
• W2022989013 creator A5057193969 @default.
• W2022989013 creator A5066014367 @default.
• W2022989013 creator A5077040670 @default.
• W2022989013 date "1988-03-01" @default.
• W2022989013 modified "2023-09-30" @default.
• W2022989013 title "Clinical application of monoclonal antibody-drug conjugates for immunotargeting chemotherapy of colorectal carcinoma" @default.
• W2022989013 cites W137281929 @default.
• W2022989013 cites W1508702630 @default.
• W2022989013 cites W1965512850 @default.
• W2022989013 cites W1977937475 @default.
• W2022989013 cites W2003956183 @default.
• W2022989013 cites W2007918406 @default.
• W2022989013 cites W2039546465 @default.
• W2022989013 cites W2069057366 @default.
• W2022989013 cites W2069681281 @default.
• W2022989013 cites W2083522107 @default.
• W2022989013 cites W2105465959 @default.
• W2022989013 cites W2149413200 @default.
• W2022989013 cites W2157575661 @default.
• W2022989013 cites W2318965166 @default.
• W2022989013 cites W2328488696 @default.
• W2022989013 doi "https://doi.org/10.1002/1097-0142(19880301)61:5<881::aid-cncr2820610505>3.0.co;2-y" @default.
• W2022989013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2962733" @default.
• W2022989013 hasPublicationYear "1988" @default.
• W2022989013 type Work @default.
• W2022989013 sameAs 2022989013 @default.
• W2022989013 citedByCount "89" @default.
• W2022989013 countsByYear W20229890132020 @default.
• W2022989013 countsByYear W20229890132021 @default.
• W2022989013 crossrefType "journal-article" @default.
• W2022989013 hasAuthorship W2022989013A5000369038 @default.
• W2022989013 hasAuthorship W2022989013A5012278399 @default.
• W2022989013 hasAuthorship W2022989013A5015752932 @default.
• W2022989013 hasAuthorship W2022989013A5016529985 @default.
• W2022989013 hasAuthorship W2022989013A5023526632 @default.
• W2022989013 hasAuthorship W2022989013A5044318331 @default.
• W2022989013 hasAuthorship W2022989013A5057193969 @default.
• W2022989013 hasAuthorship W2022989013A5066014367 @default.
• W2022989013 hasAuthorship W2022989013A5077040670 @default.
• W2022989013 hasConcept C121608353 @default.
• W2022989013 hasConcept C126322002 @default.
• W2022989013 hasConcept C134306372 @default.
• W2022989013 hasConcept C141071460 @default.
• W2022989013 hasConcept C142724271 @default.
• W2022989013 hasConcept C159654299 @default.
• W2022989013 hasConcept C197336794 @default.
• W2022989013 hasConcept C203014093 @default.
• W2022989013 hasConcept C2776146153 @default.
• W2022989013 hasConcept C2776694085 @default.
• W2022989013 hasConcept C2777064799 @default.
• W2022989013 hasConcept C2777392692 @default.
• W2022989013 hasConcept C2779013556 @default.
• W2022989013 hasConcept C2779338040 @default.
• W2022989013 hasConcept C33923547 @default.
• W2022989013 hasConcept C502942594 @default.
• W2022989013 hasConcept C526805850 @default.
• W2022989013 hasConcept C542903549 @default.
• W2022989013 hasConcept C54355233 @default.
• W2022989013 hasConcept C552990157 @default.
• W2022989013 hasConcept C71924100 @default.
• W2022989013 hasConcept C86803240 @default.
• W2022989013 hasConceptScore W2022989013C121608353 @default.
• W2022989013 hasConceptScore W2022989013C126322002 @default.
• W2022989013 hasConceptScore W2022989013C134306372 @default.
• W2022989013 hasConceptScore W2022989013C141071460 @default.
• W2022989013 hasConceptScore W2022989013C142724271 @default.
• W2022989013 hasConceptScore W2022989013C159654299 @default.
• W2022989013 hasConceptScore W2022989013C197336794 @default.
• W2022989013 hasConceptScore W2022989013C203014093 @default.
• W2022989013 hasConceptScore W2022989013C2776146153 @default.
• W2022989013 hasConceptScore W2022989013C2776694085 @default.
• W2022989013 hasConceptScore W2022989013C2777064799 @default.
• W2022989013 hasConceptScore W2022989013C2777392692 @default.
• W2022989013 hasConceptScore W2022989013C2779013556 @default.
• W2022989013 hasConceptScore W2022989013C2779338040 @default.
• W2022989013 hasConceptScore W2022989013C33923547 @default.
• W2022989013 hasConceptScore W2022989013C502942594 @default.
• W2022989013 hasConceptScore W2022989013C526805850 @default.
• W2022989013 hasConceptScore W2022989013C542903549 @default.
• W2022989013 hasConceptScore W2022989013C54355233 @default.
• W2022989013 hasConceptScore W2022989013C552990157 @default.
• W2022989013 hasConceptScore W2022989013C71924100 @default.
• W2022989013 hasConceptScore W2022989013C86803240 @default.
• W2022989013 hasIssue "5" @default.
• W2022989013 hasLocation W20229890131 @default.
• W2022989013 hasLocation W20229890132 @default.
• W2022989013 hasOpenAccess W2022989013 @default.
• W2022989013 hasPrimaryLocation W20229890131 @default.
• W2022989013 hasRelatedWork W1603824974 @default.
• W2022989013 hasRelatedWork W1970423756 @default.

• next