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• W2022989605 endingPage "1163" @default.
• W2022989605 startingPage "1149" @default.
• W2022989605 abstract "Lethally irradiated mice transplanted with bone marrow cells infected with a novel recombinant retrovirus (murine stem cell virus-interleukin 6 [MSCV-IL-6]) bearing a mouse IL-6 gene developed a fatal myeloproliferative disease within 4 wk of engraftment. The hematologic manifestations of the syndrome included elevated peripheral leukocyte counts (up to 430 x 10(3) cells/mm3) with a predominance of neutrophilic granulocytes, microcytic anemia, and thrombocytosis or thrombocytopenia. The mice showed extensive neutrophil infiltration of the lungs, liver, and occasionally lymph nodes, plus splenomegaly resulting from enhanced splenic myelopoiesis (30-60-fold increase in progenitor numbers). Despite the chronic stimulation of neutrophil excess by IL-6, bone marrow from affected mice was capable of repopulating the hematopoietic tissues (bone marrow and spleen) of lethally irradiated hosts during repeated serial transplantation. In the longest documented case, the progeny of a single MSCV-IL-6-marked cell transferred the myeloproliferative disease to two secondary, four tertiary, and two quaternary recipients (the clone endured for a total of 72 wk). These results, demonstrating considerable proliferative longevity of the IL-6-producing cells, support an in vivo role of IL-6 in the maintenance of hematopoietic precursors. Dysregulated IL-6 production also had significant systemic effects. The mice displayed increased mesangial cell proliferation in the kidney, frequent liver abnormalities, and marked alterations in plasma protein levels. Unlike previous studies where constitutive expression of exogenous IL-6 genes resulted in lymphoproliferative disorders characterized by massive plasmacytosis, minimal plasma cell expansion occurred in the MSCV-IL-6 mice during the observation period. Potential explanations for the differences in disease phenotypes observed in the present and previous studies are different cell types expressing the exogenous IL-6 genes, higher sustained circulating levels of IL-6 achieved using the MSCV-IL-6 retroviral delivery system, and/or the premature death (3-15 wk after transplantation) of the MSCV-IL-6 mice before the onset of plasmacytosis. This animal model should prove useful for further investigation of the function of IL-6 in normal and abnormal hematopoiesis and in inflammatory responses." @default.
• W2022989605 created "2016-06-24" @default.
• W2022989605 creator A5031658033 @default.
• W2022989605 creator A5041887636 @default.
• W2022989605 creator A5062912095 @default.
• W2022989605 creator A5073045951 @default.
• W2022989605 date "1992-10-01" @default.
• W2022989605 modified "2023-10-17" @default.
• W2022989605 title "Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus." @default.
• W2022989605 cites W109291748 @default.
• W2022989605 cites W133768150 @default.
• W2022989605 cites W1489777708 @default.
• W2022989605 cites W1500033451 @default.
• W2022989605 cites W1517056268 @default.
• W2022989605 cites W1563221652 @default.
• W2022989605 cites W1602618889 @default.
• W2022989605 cites W1750539994 @default.
• W2022989605 cites W1814728082 @default.
• W2022989605 cites W190052799 @default.
• W2022989605 cites W1904539417 @default.
• W2022989605 cites W1923202625 @default.
• W2022989605 cites W1937917212 @default.
• W2022989605 cites W1968075576 @default.
• W2022989605 cites W1972816013 @default.
• W2022989605 cites W1972932855 @default.
• W2022989605 cites W1975997182 @default.
• W2022989605 cites W1992704301 @default.
• W2022989605 cites W1997257161 @default.
• W2022989605 cites W199734720 @default.
• W2022989605 cites W2000602253 @default.
• W2022989605 cites W2004650098 @default.
• W2022989605 cites W2006425208 @default.
• W2022989605 cites W2006448209 @default.
• W2022989605 cites W2007177867 @default.
• W2022989605 cites W2007319015 @default.
• W2022989605 cites W2008634652 @default.
• W2022989605 cites W2016011359 @default.
• W2022989605 cites W2016647073 @default.
• W2022989605 cites W2017379138 @default.
• W2022989605 cites W2022205235 @default.
• W2022989605 cites W2023972192 @default.
• W2022989605 cites W2024577717 @default.
• W2022989605 cites W2034296167 @default.
• W2022989605 cites W2034712245 @default.
• W2022989605 cites W2036452124 @default.
• W2022989605 cites W2037719060 @default.
• W2022989605 cites W2039241519 @default.
• W2022989605 cites W2039305351 @default.
• W2022989605 cites W2040879840 @default.
• W2022989605 cites W2052579278 @default.
• W2022989605 cites W2053970213 @default.
• W2022989605 cites W2054663403 @default.
• W2022989605 cites W2054925586 @default.
• W2022989605 cites W2057637494 @default.
• W2022989605 cites W2058319782 @default.
• W2022989605 cites W2060912271 @default.
• W2022989605 cites W2064144011 @default.
• W2022989605 cites W2066352920 @default.
• W2022989605 cites W2066896666 @default.
• W2022989605 cites W2070076558 @default.
• W2022989605 cites W2076529943 @default.
• W2022989605 cites W2084665581 @default.
• W2022989605 cites W2085264697 @default.
• W2022989605 cites W2092691564 @default.
• W2022989605 cites W2097857054 @default.
• W2022989605 cites W2105020114 @default.
• W2022989605 cites W2106786890 @default.
• W2022989605 cites W2111759041 @default.
• W2022989605 cites W2122248986 @default.
• W2022989605 cites W2128006259 @default.
• W2022989605 cites W2132379795 @default.
• W2022989605 cites W2135392289 @default.
• W2022989605 cites W2154992787 @default.
• W2022989605 cites W2158800860 @default.
• W2022989605 cites W2161524167 @default.
• W2022989605 cites W2173595496 @default.
• W2022989605 cites W2298584763 @default.
• W2022989605 cites W229871711 @default.
• W2022989605 cites W2344986489 @default.
• W2022989605 cites W236737518 @default.
• W2022989605 cites W2408857414 @default.
• W2022989605 cites W2410169983 @default.
• W2022989605 cites W2410558537 @default.
• W2022989605 cites W2415350797 @default.
• W2022989605 cites W2418048479 @default.
• W2022989605 cites W2418064775 @default.
• W2022989605 cites W2419143732 @default.
• W2022989605 cites W2440010918 @default.
• W2022989605 cites W2460106530 @default.
• W2022989605 cites W292708302 @default.
• W2022989605 cites W322263802 @default.
• W2022989605 cites W4290207247 @default.
• W2022989605 cites W621243529 @default.
• W2022989605 doi "https://doi.org/10.1084/jem.176.4.1149" @default.
• W2022989605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2119383" @default.
• W2022989605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1402659" @default.
• W2022989605 hasPublicationYear "1992" @default.
• W2022989605 type Work @default.

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