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- W2022989795 abstract "The relative dose response (RDR) has been proposed as a method for the estimation of body vitamin A stores and has been tested in children suffering from various grades of malnutrition. RDR was tested before and after 4–6 days of vitamin A administration either as a single massive oral dose of 200,000 i.u. or four smaller doses of 50,000 i.u. each. The results of the study indicated a positive RDR (> 14%) reflecting liver stores depletion in children whose serum levels of vitamin A were less than 0.35 μmol/l. Normal RDR (< 14%) was observed in children whose serum levels of vitamin A were above 0.7 μmol/l indicating normal liver vitamin A reserves. However, the RDR showed variable results in children whose serum vitamin A levels were between 0.35–0.70 μmol. Eleven out of 49 children continued to show positive RDR even after vitamin A supplementation. Associated malnutrition might be responsible for the variation in the response. These results suggest that RDR test may be of a limited value in populations where malnutrition is prevalent." @default.
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- W2022989795 date "1998-03-01" @default.
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- W2022989795 title "Vitamin a relative dose response test in undernourished children" @default.
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- W2022989795 doi "https://doi.org/10.1016/s0271-5317(98)00040-2" @default.
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