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• W2022991261 endingPage "595" @default.
• W2022991261 startingPage "584" @default.
• W2022991261 abstract "Activator protein (AP)-1 family members play important roles in the development and maintenance of the adult skeleton. Transgenic mice that overexpress the naturally occurring DeltaFosB splice variant of FosB develop severe osteosclerosis. Translation of Deltafosb mRNA produces both DeltaFosB and a further truncated isoform (Delta2DeltaFosB) that lacks known transactivation domains but, like DeltaFosB, induces increased expression of osteoblast marker genes.To test Delta2DeltaFosB's ability to induce bone formation in vivo, we generated transgenic mice that overexpress only Delta2DeltaFosB using the enolase 2 (ENO2) promoter-driven bitransgenic Tet-Off system.Despite Delta2DeltaFosB's failure to induce transcription of an AP-1 reporter gene, the transgenic mice exhibited both the bone and the fat phenotypes seen in the ENO2-DeltaFosB mice. Both DeltaFosB and Delta2DeltaFosB activated the BMP-responsive Xvent-luc reporter gene and increased Smad1 expression. Delta2DeltaFosB enhanced BMP-induced Smad1 phosphorylation and the translocation of phospho-Smad1 (pSmad1) to the nucleus more efficiently than DeltaFosB and showed a reduced induction of inhibitory Smad6 expression.DeltaFosB's AP-1 transactivating function is not needed to induce increased bone formation, and Delta2DeltaFosB may act, at least in part, by increasing Smad1 expression, phosphorylation, and translocation to the nucleus." @default.
• W2022991261 created "2016-06-24" @default.
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• W2022991261 date "2008-02-04" @default.
• W2022991261 modified "2023-09-23" @default.
• W2022991261 title "Doubly Truncated FosB Isoform (Δ2ΔFosB) Induces Osteosclerosis in Transgenic Mice and Modulates Expression and Phosphorylation of Smads in Osteoblasts Independent of Intrinsic AP-1 Activity" @default.
• W2022991261 cites W134943579 @default.
• W2022991261 cites W1487599137 @default.
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• W2022991261 cites W1599501164 @default.
• W2022991261 cites W1858153082 @default.
• W2022991261 cites W1911745723 @default.
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• W2022991261 doi "https://doi.org/10.1359/jbmr.080110" @default.
• W2022991261 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2674536" @default.
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