FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022991367> ?p ?o ?g. }

• W2022991367 endingPage "258" @default.
• W2022991367 startingPage "249" @default.
• W2022991367 abstract "The articular cartilage and the subchondral bone form a biocomposite that is uniquely adapted to the transfer of loads across the diarthrodial joint. During the evolution of the osteoarthritic process biomechanical and biological processes result in alterations in the composition, structure and functional properties of these tissues. Given the intimate contact between the cartilage and bone, alterations of either tissue will modulate the properties and function of the other joint component. The changes in periarticular bone tend to occur very early in the development of OA. Although chondrocytes also have the capacity to modulate their functional state in response to loading, the capacity of these cells to repair and modify their surrounding extracellular matrix is relatively limited in comparison to the adjacent subchondral bone. This differential adaptive capacity likely underlies the more rapid appearance of detectable skeletal changes in OA in comparison to the articular cartilage. The OA changes in periarticular bone include increases in subchondral cortical bone thickness, gradual decreases in subchondral trabeular bone mass, formation of marginal joint osteophytes, development of bone cysts and advancement of the zone of calcified cartilage between the articular cartilage and subchondral bone. The expansion of the zone of calcified cartilage contributes to overall thinning of the articular cartilage. The mechanisms involved in this process include the release of soluble mediators from chondrocytes in the deep zones of the articular cartilage and/or the influences of microcracks that have initiated focal remodeling in the calcified cartilage and subchondral bone in an attempt to repair the microdamage. There is the need for further studies to define the pathophysiological mechanisms involved in the interaction between subchondral bone and articular cartilage and for applying this information to the development of therapeutic interventions to improve the outcomes in patients with OA." @default.
• W2022991367 created "2016-06-24" @default.
• W2022991367 creator A5080984126 @default.
• W2022991367 date "2012-07-24" @default.
• W2022991367 modified "2023-10-12" @default.
• W2022991367 title "Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis" @default.
• W2022991367 cites W1551310212 @default.
• W2022991367 cites W1591811676 @default.
• W2022991367 cites W1618293427 @default.
• W2022991367 cites W1694204358 @default.
• W2022991367 cites W1774678646 @default.
• W2022991367 cites W1954475373 @default.
• W2022991367 cites W1974485477 @default.
• W2022991367 cites W1974957510 @default.
• W2022991367 cites W1976089856 @default.
• W2022991367 cites W1976595521 @default.
• W2022991367 cites W1985935843 @default.
• W2022991367 cites W1989723752 @default.
• W2022991367 cites W1990844960 @default.
• W2022991367 cites W1991556961 @default.
• W2022991367 cites W1996161852 @default.
• W2022991367 cites W1997637714 @default.
• W2022991367 cites W1999775304 @default.
• W2022991367 cites W2003270450 @default.
• W2022991367 cites W2005381591 @default.
• W2022991367 cites W2006577709 @default.
• W2022991367 cites W2007811809 @default.
• W2022991367 cites W2011407969 @default.
• W2022991367 cites W2015430681 @default.
• W2022991367 cites W2021115829 @default.
• W2022991367 cites W2023881992 @default.
• W2022991367 cites W2024131080 @default.
• W2022991367 cites W2025781283 @default.
• W2022991367 cites W2028638219 @default.
• W2022991367 cites W2028949281 @default.
• W2022991367 cites W2029932944 @default.
• W2022991367 cites W2030453203 @default.
• W2022991367 cites W2032306447 @default.
• W2022991367 cites W2035213351 @default.
• W2022991367 cites W2036349883 @default.
• W2022991367 cites W2038701776 @default.
• W2022991367 cites W2039173239 @default.
• W2022991367 cites W2039488563 @default.
• W2022991367 cites W2044000768 @default.
• W2022991367 cites W2050113739 @default.
• W2022991367 cites W2053338769 @default.
• W2022991367 cites W2057491978 @default.
• W2022991367 cites W2060693812 @default.
• W2022991367 cites W2063375226 @default.
• W2022991367 cites W2064929623 @default.
• W2022991367 cites W2065489193 @default.
• W2022991367 cites W2072655277 @default.
• W2022991367 cites W2074016034 @default.
• W2022991367 cites W2082512681 @default.
• W2022991367 cites W2084085870 @default.
• W2022991367 cites W2086257914 @default.
• W2022991367 cites W2087317356 @default.
• W2022991367 cites W2093625328 @default.
• W2022991367 cites W2095099053 @default.
• W2022991367 cites W2099647314 @default.
• W2022991367 cites W2103678779 @default.
• W2022991367 cites W2106478572 @default.
• W2022991367 cites W2113905699 @default.
• W2022991367 cites W2121144887 @default.
• W2022991367 cites W2122586325 @default.
• W2022991367 cites W2135213015 @default.
• W2022991367 cites W2136348406 @default.
• W2022991367 cites W2137637067 @default.
• W2022991367 cites W2138475419 @default.
• W2022991367 cites W2156140663 @default.
• W2022991367 cites W2159097703 @default.
• W2022991367 cites W2159636837 @default.
• W2022991367 cites W2160233743 @default.
• W2022991367 cites W2160510281 @default.
• W2022991367 cites W2160726216 @default.
• W2022991367 cites W2162085535 @default.
• W2022991367 cites W2163615538 @default.
• W2022991367 cites W2163625752 @default.
• W2022991367 cites W2167933345 @default.
• W2022991367 cites W2168016554 @default.
• W2022991367 cites W4232900352 @default.
• W2022991367 doi "https://doi.org/10.1177/1759720x12437353" @default.
• W2022991367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3403248" @default.
• W2022991367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22859924" @default.
• W2022991367 hasPublicationYear "2012" @default.
• W2022991367 type Work @default.
• W2022991367 sameAs 2022991367 @default.
• W2022991367 citedByCount "137" @default.
• W2022991367 countsByYear W20229913672013 @default.
• W2022991367 countsByYear W20229913672014 @default.
• W2022991367 countsByYear W20229913672015 @default.
• W2022991367 countsByYear W20229913672016 @default.
• W2022991367 countsByYear W20229913672017 @default.
• W2022991367 countsByYear W20229913672018 @default.
• W2022991367 countsByYear W20229913672019 @default.
• W2022991367 countsByYear W20229913672020 @default.
• W2022991367 countsByYear W20229913672021 @default.
• W2022991367 countsByYear W20229913672022 @default.

• next