FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022991620> ?p ?o ?g. }

• W2022991620 endingPage "77" @default.
• W2022991620 startingPage "68" @default.
• W2022991620 abstract "Our previous studies have shown that there is a lower cGMP concentration in the aged brain as well as an alteration in the activity of cGMP-hydrolyzing phosphodiesterases (PDEs) and nitric oxide synthase (NOS). The aim of this study was to investigate the effect of specific inhibitors of selected PDEs on object recognition memory and locomotor activity during aging, and to correlate their action with NOS activity in the following brain regions: hippocampus, striatum, and cerebral cortex. The study was carried out using 3, 12, and 24 month-old rats. Inhibitors of PDE2 and PDE5 (Bayer 60-7550 and zaprinast, respectively) were used. Evaluation of memory and locomotor activity was carried out using an object recognition task and the open field test. NOS activity was determined using a radiochemical method after behavioral analysis in the cytosolic fraction from all brain areas investigated. We have found that the inhibitor of PDE2, Bay60-7550, improves object recognition memory in all age groups investigated and increases basal constitutive NOS activity in the hippocampus and striatum. Moreover, in 3 month-old rats, additional inhibition of PDE5 by zaprinast improves object memory and elevates NOS activity in all brain regions studied. Specific inhibition of nNOS eliminates the effect of Bay60-7550 on memory function and on NOS activity in 24 month-old rats. In summary, our results indicate that inhibition of PDE2 is able to improve cognition and memory function in 3, 12, and 24 month-old rats through the enhancement of nNOS activity in the brain, whereas inhibition of PDE5 is effective only in 3 month-old animals." @default.
• W2022991620 created "2016-06-24" @default.
• W2022991620 creator A5000724983 @default.
• W2022991620 creator A5029245325 @default.
• W2022991620 date "2008-06-01" @default.
• W2022991620 modified "2023-10-18" @default.
• W2022991620 title "The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging" @default.
• W2022991620 cites W1493697019 @default.
• W2022991620 cites W1577523067 @default.
• W2022991620 cites W173393522 @default.
• W2022991620 cites W1960607431 @default.
• W2022991620 cites W1963889489 @default.
• W2022991620 cites W1966322594 @default.
• W2022991620 cites W1966431705 @default.
• W2022991620 cites W1967287608 @default.
• W2022991620 cites W1967756241 @default.
• W2022991620 cites W1975482089 @default.
• W2022991620 cites W1977223788 @default.
• W2022991620 cites W1978804144 @default.
• W2022991620 cites W1984628764 @default.
• W2022991620 cites W1985735468 @default.
• W2022991620 cites W1986131501 @default.
• W2022991620 cites W1987935978 @default.
• W2022991620 cites W1995597122 @default.
• W2022991620 cites W1997686526 @default.
• W2022991620 cites W2000843849 @default.
• W2022991620 cites W2005209827 @default.
• W2022991620 cites W2008791980 @default.
• W2022991620 cites W2012285288 @default.
• W2022991620 cites W2023102502 @default.
• W2022991620 cites W2028655076 @default.
• W2022991620 cites W2036416179 @default.
• W2022991620 cites W2039996678 @default.
• W2022991620 cites W2046096942 @default.
• W2022991620 cites W2049268124 @default.
• W2022991620 cites W2050597447 @default.
• W2022991620 cites W2058616055 @default.
• W2022991620 cites W2061254866 @default.
• W2022991620 cites W2062218685 @default.
• W2022991620 cites W2062225147 @default.
• W2022991620 cites W2064376284 @default.
• W2022991620 cites W2065388112 @default.
• W2022991620 cites W2065596380 @default.
• W2022991620 cites W2070412886 @default.
• W2022991620 cites W2071293996 @default.
• W2022991620 cites W2071331983 @default.
• W2022991620 cites W2072441360 @default.
• W2022991620 cites W2072670269 @default.
• W2022991620 cites W2084553897 @default.
• W2022991620 cites W2085470496 @default.
• W2022991620 cites W2089987432 @default.
• W2022991620 cites W2096706827 @default.
• W2022991620 cites W2117658342 @default.
• W2022991620 cites W2124333932 @default.
• W2022991620 cites W2130188089 @default.
• W2022991620 cites W2143070083 @default.
• W2022991620 cites W2146896966 @default.
• W2022991620 cites W2154264553 @default.
• W2022991620 cites W2159483285 @default.
• W2022991620 cites W2169566060 @default.
• W2022991620 cites W2911414414 @default.
• W2022991620 doi "https://doi.org/10.1016/j.brainres.2008.02.108" @default.
• W2022991620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18499090" @default.
• W2022991620 hasPublicationYear "2008" @default.
• W2022991620 type Work @default.
• W2022991620 sameAs 2022991620 @default.
• W2022991620 citedByCount "111" @default.
• W2022991620 countsByYear W20229916202012 @default.
• W2022991620 countsByYear W20229916202013 @default.
• W2022991620 countsByYear W20229916202014 @default.
• W2022991620 countsByYear W20229916202015 @default.
• W2022991620 countsByYear W20229916202016 @default.
• W2022991620 countsByYear W20229916202017 @default.
• W2022991620 countsByYear W20229916202018 @default.
• W2022991620 countsByYear W20229916202019 @default.
• W2022991620 countsByYear W20229916202020 @default.
• W2022991620 countsByYear W20229916202021 @default.
• W2022991620 countsByYear W20229916202022 @default.
• W2022991620 countsByYear W20229916202023 @default.
• W2022991620 crossrefType "journal-article" @default.
• W2022991620 hasAuthorship W2022991620A5000724983 @default.
• W2022991620 hasAuthorship W2022991620A5029245325 @default.
• W2022991620 hasConcept C126322002 @default.
• W2022991620 hasConcept C15744967 @default.
• W2022991620 hasConcept C169760540 @default.
• W2022991620 hasConcept C178790620 @default.
• W2022991620 hasConcept C181199279 @default.
• W2022991620 hasConcept C185592680 @default.
• W2022991620 hasConcept C2776846068 @default.
• W2022991620 hasConcept C2777622882 @default.
• W2022991620 hasConcept C2779929075 @default.
• W2022991620 hasConcept C2780062018 @default.
• W2022991620 hasConcept C2781161787 @default.
• W2022991620 hasConcept C2909202170 @default.
• W2022991620 hasConcept C513476851 @default.
• W2022991620 hasConcept C519581460 @default.
• W2022991620 hasConcept C55493867 @default.
• W2022991620 hasConcept C62826618 @default.

• next