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• W2022991708 abstract "Aim: It has been shown that atherosclerosis is an inflammatory disease. Recent data suggest that inflammation precedes type 2 diabetes. Hence, we wanted to study the interrelationship between IL‐6, insulin sensitivity, lipids and numerous acute‐phase proteins. Methods: Twenty‐one healthy individuals [16 males/5 females, age 27.9 ± 1.8 years, body mass index (BMI) 24.1 ± 0.8 kg/m 2 ] participated in the study. Each patient went through a 4‐h hyperinsulinaemic (40 mU/m 2 /min) euglycaemic clamp and 4‐h saline infusion. Blood samples were taken before and at the end of the infusions. Results: Plasma interleukin (IL)‐6 concentration correlated inversely with insulin sensitivity ( M ‐value) (r = −0.49, p < 0.05). Moreover, the plasma levels of IL‐6 associated with c‐peptide (r = 0.49, p < 0.05), fat% (r = 0.43, p < 0.05) and diastolic blood pressure (r = 0.46, p < 0.05). α‐1‐acid glycoprotein was related to HbA1 c (r = 0.47, p < 0.05), insulin (r = 0.55, p < 0.01), diastolic blood pressure (r = 0.58, p < 0.01), systolic blood pressure (r = 0.58, p < 0.01) and triglycerides (r = 0.58, p < 0.01). Haptoglobin was correlated with insulin (r = 0.46, p < 0.05), total cholesterol (r = 0.61, p < 0.01), BMI (r = 0.58, p < 0.01), fat% (r = 0.63, p < 0.01) and lipid oxidation during clamp (r = 0.43, p < 0.05). Diastolic blood pressure decreased during the clamp (from 78.3 ± 1.9 to 72.1 ± 2.0 mmHg, p = 0.001). Insulin infusion did not affect the serum levels of most acute‐phase proteins. Conclusions: Our study suggests that low grade inflammation, as reflected by IL‐6, A1GP and haptoglobin contributes to the regulation of insulin sensitivity, lipid metabolism and blood pressure in normal human physiology." @default.
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• W2022991708 date "2004-12-21" @default.
• W2022991708 modified "2023-10-16" @default.
• W2022991708 title "Plasma IL‐6 concentration is inversely related to insulin sensitivity, and acute‐phase proteins associate with glucose and lipid metabolism in healthy subjects" @default.
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• W2022991708 doi "https://doi.org/10.1111/j.1463-1326.2004.00463.x" @default.
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