Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022993506> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2022993506 endingPage "191" @default.
- W2022993506 startingPage "184" @default.
- W2022993506 abstract "Phenanthrenequinone (PQ), which occurs widely as a pollutant and as a major metabolite of phenanthrene in a number of species, has been demonstrated to undergo futile redox cycling leading to oxidative stress. In the presence of cytosolic fractions of selected channel catfish tissues, PQ undergoes enzymatic reduction which is mediated by either NADH or NADPH and is composed of dicoumarol-sensitive and -insensitive components. Most notably, gastric cytosol catalyzed a disproportionately high level of NADPH-dependent, dicoumarol-sensitive PQ reduction as compared to gill, liver, and kidney cytosols. In the presence of stomach cytosol and NADPH, PQ facilitated production of superoxide anion at rates several fold higher than those mediated by menadione. The dicoumarol-sensitive PQ-reducing agent, which we have termed NADPH: phenanthrenequinone oxidoreductase (PQR), was purified by affinity chromatography and was demonstrated to be separable from DT diaphorase activity in gastric cytosol. Under aerobic conditions, purified PQR facilitates redox cycling of PQ as indicated by continued NADPH oxidation and hydrogen peroxide production. Under anaerobic conditions, NADPH oxidation is limited to a quantity indicative of PQ reduction to the hydroquinone. Substrate specificities, pH profiles, and kinetic characteristics combine to indicate that PQR represents a novel quinone reductase in this species." @default.
- W2022993506 created "2016-06-24" @default.
- W2022993506 creator A5001852113 @default.
- W2022993506 creator A5014056801 @default.
- W2022993506 date "1994-04-01" @default.
- W2022993506 modified "2023-10-11" @default.
- W2022993506 title "Dicoumarol-Sensitive NADPH: Phenanthrenequinone Oxidoreductase in Channel Catfish (Ictalurus punctatus)" @default.
- W2022993506 doi "https://doi.org/10.1006/taap.1994.1063" @default.
- W2022993506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7513448" @default.
- W2022993506 hasPublicationYear "1994" @default.
- W2022993506 type Work @default.
- W2022993506 sameAs 2022993506 @default.
- W2022993506 citedByCount "15" @default.
- W2022993506 countsByYear W20229935062012 @default.
- W2022993506 countsByYear W20229935062015 @default.
- W2022993506 countsByYear W20229935062017 @default.
- W2022993506 countsByYear W20229935062021 @default.
- W2022993506 crossrefType "journal-article" @default.
- W2022993506 hasAuthorship W2022993506A5001852113 @default.
- W2022993506 hasAuthorship W2022993506A5014056801 @default.
- W2022993506 hasConcept C181199279 @default.
- W2022993506 hasConcept C185592680 @default.
- W2022993506 hasConcept C2777990912 @default.
- W2022993506 hasConcept C2778189562 @default.
- W2022993506 hasConcept C2778949639 @default.
- W2022993506 hasConcept C2779268744 @default.
- W2022993506 hasConcept C2780795997 @default.
- W2022993506 hasConcept C2781095387 @default.
- W2022993506 hasConcept C2909208804 @default.
- W2022993506 hasConcept C505870484 @default.
- W2022993506 hasConcept C533411734 @default.
- W2022993506 hasConcept C55493867 @default.
- W2022993506 hasConcept C75520062 @default.
- W2022993506 hasConcept C86803240 @default.
- W2022993506 hasConcept C98539663 @default.
- W2022993506 hasConceptScore W2022993506C181199279 @default.
- W2022993506 hasConceptScore W2022993506C185592680 @default.
- W2022993506 hasConceptScore W2022993506C2777990912 @default.
- W2022993506 hasConceptScore W2022993506C2778189562 @default.
- W2022993506 hasConceptScore W2022993506C2778949639 @default.
- W2022993506 hasConceptScore W2022993506C2779268744 @default.
- W2022993506 hasConceptScore W2022993506C2780795997 @default.
- W2022993506 hasConceptScore W2022993506C2781095387 @default.
- W2022993506 hasConceptScore W2022993506C2909208804 @default.
- W2022993506 hasConceptScore W2022993506C505870484 @default.
- W2022993506 hasConceptScore W2022993506C533411734 @default.
- W2022993506 hasConceptScore W2022993506C55493867 @default.
- W2022993506 hasConceptScore W2022993506C75520062 @default.
- W2022993506 hasConceptScore W2022993506C86803240 @default.
- W2022993506 hasConceptScore W2022993506C98539663 @default.
- W2022993506 hasIssue "2" @default.
- W2022993506 hasLocation W20229935061 @default.
- W2022993506 hasLocation W20229935062 @default.
- W2022993506 hasOpenAccess W2022993506 @default.
- W2022993506 hasPrimaryLocation W20229935061 @default.
- W2022993506 hasRelatedWork W1780018939 @default.
- W2022993506 hasRelatedWork W1967288224 @default.
- W2022993506 hasRelatedWork W1978976972 @default.
- W2022993506 hasRelatedWork W1993754796 @default.
- W2022993506 hasRelatedWork W2076839510 @default.
- W2022993506 hasRelatedWork W2088656987 @default.
- W2022993506 hasRelatedWork W2108331928 @default.
- W2022993506 hasRelatedWork W2981856880 @default.
- W2022993506 hasRelatedWork W3159068225 @default.
- W2022993506 hasRelatedWork W3168090045 @default.
- W2022993506 hasVolume "125" @default.
- W2022993506 isParatext "false" @default.
- W2022993506 isRetracted "false" @default.
- W2022993506 magId "2022993506" @default.
- W2022993506 workType "article" @default.