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• W2022994076 abstract "Geniposidic acid (GA) is an iridoid glucoside isolated from Gardeniae jasminoides Ellis (Rubiaceae) that has long been used to treat inflammation, jaundice and hepatic disorders. This study examined the cytoprotective properties of GA against d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure. Mice were given an intraperitoneal injection of GA (12.5, 25, 50 mg/kg) 1 h before receiving GalN (800 mg/kg)/LPS (40 μg/kg). Liver and blood samples were collected 1 and 8 h after GalN/LPS injection. The survival rate of the GA group was significantly higher than the control. GalN/LPS increased serum aminotransferase activity, serum tumor necrosis factor-α level and hepatic lipid peroxidation and decreased hepatic glutathione content. These changes were attenuated by GA. GA augmented increases in serum interleukin-6 level, heme oxygenase-1 and NF-E2-related factor 2 protein expression. Mice treated with GA decreased cleaved caspase-8 and caspase-3 protein expression and showed significantly fewer apoptotic cells. GA increased Bcl-xL protein expression and decreased Bax protein expression. Moreover, GA treatment enhanced phosphorylation of signal transducer and activator of transcription 3. Our findings suggest that geniposidic acid alleviates GalN/LPS-induced liver injury by enhancing antioxidative defense system and reducing apoptotic signaling pathways." @default.
• W2022994076 created "2016-06-24" @default.
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• W2022994076 date "2013-03-01" @default.
• W2022994076 modified "2023-09-23" @default.
• W2022994076 title "Geniposidic acid protects against d-galactosamine and lipopolysaccharide-induced hepatic failure in mice" @default.
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• W2022994076 doi "https://doi.org/10.1016/j.jep.2012.12.042" @default.
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