Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022994460> ?p ?o ?g. }
- W2022994460 endingPage "206" @default.
- W2022994460 startingPage "198" @default.
- W2022994460 abstract "Type III lambda interferons (IFNs) have activity similar to type I IFNs, but a more restricted receptor distribution. A pegylated human IFN lambda-1 (pegIFNλ) is under development for chronic hepatitis C. Induction of receptor signaling (STAT1 phosphorylation) and expression of interferon-stimulated genes (ISGs) by pegIFNλ were assessed in, respectively, cynomolgus monkey leukocyte subsets and hepatocytes stimulated in vitro. ISG induction by pegIFNλ or IFNα was also assessed in peripheral leukocytes and liver biopsies after single and repeat (x3) dosing of pegIFNλ (0.03, 0.3, 3.0 mg/kg) or unpegylated IFNα-2b (107 IU/kg). Single-dose pharmacokinetics of pegIFNλ were evaluated. Strong ISG induction occurred in cultured hepatocytes and liver biopsies with both pegIFNλ and IFNα. However, STAT1 phosphorylation, MHC class 1 upregulation, and ISG induction in leukocytes only occurred with IFNα. Serum neopterin was unaffected by pegIFNλ; however, β-2-microglobulin was elevated at all doses. The terminal half-life of pegIFNλ was 23 h with a 59 mL/kg volume of distribution, consistent with other pegylated IFNs. Serum exposure was dose-proportional across the dosing range. These data demonstrate the suitability of cynomolgus monkeys for the preclinical evaluation of pegIFNλ. Additionally, the absence of pegIFNλ pharmacologic activity in leukocytes is consistent with its low receptor expression in blood." @default.
- W2022994460 created "2016-06-24" @default.
- W2022994460 creator A5006927893 @default.
- W2022994460 creator A5020747557 @default.
- W2022994460 creator A5033878540 @default.
- W2022994460 creator A5037987534 @default.
- W2022994460 creator A5060735933 @default.
- W2022994460 creator A5077642969 @default.
- W2022994460 creator A5086715649 @default.
- W2022994460 date "2012-05-01" @default.
- W2022994460 modified "2023-09-26" @default.
- W2022994460 title "Pharmacokinetics and Pharmacodynamics of Pegylated Interferon Lambda-1 in Cynomolgus Monkeys" @default.
- W2022994460 cites W110928060 @default.
- W2022994460 cites W152943885 @default.
- W2022994460 cites W1980221984 @default.
- W2022994460 cites W1987009823 @default.
- W2022994460 cites W1988025623 @default.
- W2022994460 cites W1992210588 @default.
- W2022994460 cites W2013202475 @default.
- W2022994460 cites W2017896938 @default.
- W2022994460 cites W2021797151 @default.
- W2022994460 cites W2031541196 @default.
- W2022994460 cites W2032980717 @default.
- W2022994460 cites W2033856426 @default.
- W2022994460 cites W2041829128 @default.
- W2022994460 cites W2044987809 @default.
- W2022994460 cites W2047984410 @default.
- W2022994460 cites W2056366256 @default.
- W2022994460 cites W2060860123 @default.
- W2022994460 cites W2060926084 @default.
- W2022994460 cites W2068931925 @default.
- W2022994460 cites W2069013641 @default.
- W2022994460 cites W2069870848 @default.
- W2022994460 cites W2072171359 @default.
- W2022994460 cites W2078502580 @default.
- W2022994460 cites W2083733004 @default.
- W2022994460 cites W2085237060 @default.
- W2022994460 cites W2100396313 @default.
- W2022994460 cites W2107830237 @default.
- W2022994460 cites W2119834166 @default.
- W2022994460 cites W2130322554 @default.
- W2022994460 cites W2144580269 @default.
- W2022994460 cites W2157135427 @default.
- W2022994460 cites W2165233139 @default.
- W2022994460 cites W2174253635 @default.
- W2022994460 cites W2177943720 @default.
- W2022994460 cites W2332992445 @default.
- W2022994460 doi "https://doi.org/10.1089/jir.2011.0075" @default.
- W2022994460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22280056" @default.
- W2022994460 hasPublicationYear "2012" @default.
- W2022994460 type Work @default.
- W2022994460 sameAs 2022994460 @default.
- W2022994460 citedByCount "8" @default.
- W2022994460 countsByYear W20229944602012 @default.
- W2022994460 countsByYear W20229944602013 @default.
- W2022994460 countsByYear W20229944602014 @default.
- W2022994460 countsByYear W20229944602016 @default.
- W2022994460 countsByYear W20229944602021 @default.
- W2022994460 countsByYear W20229944602022 @default.
- W2022994460 crossrefType "journal-article" @default.
- W2022994460 hasAuthorship W2022994460A5006927893 @default.
- W2022994460 hasAuthorship W2022994460A5020747557 @default.
- W2022994460 hasAuthorship W2022994460A5033878540 @default.
- W2022994460 hasAuthorship W2022994460A5037987534 @default.
- W2022994460 hasAuthorship W2022994460A5060735933 @default.
- W2022994460 hasAuthorship W2022994460A5077642969 @default.
- W2022994460 hasAuthorship W2022994460A5086715649 @default.
- W2022994460 hasConcept C111113717 @default.
- W2022994460 hasConcept C112705442 @default.
- W2022994460 hasConcept C203014093 @default.
- W2022994460 hasConcept C2522874641 @default.
- W2022994460 hasConcept C2776178377 @default.
- W2022994460 hasConcept C2776408679 @default.
- W2022994460 hasConcept C2776461080 @default.
- W2022994460 hasConcept C2776603314 @default.
- W2022994460 hasConcept C2777003663 @default.
- W2022994460 hasConcept C2777288759 @default.
- W2022994460 hasConcept C2780040827 @default.
- W2022994460 hasConcept C71924100 @default.
- W2022994460 hasConcept C86803240 @default.
- W2022994460 hasConcept C98274493 @default.
- W2022994460 hasConceptScore W2022994460C111113717 @default.
- W2022994460 hasConceptScore W2022994460C112705442 @default.
- W2022994460 hasConceptScore W2022994460C203014093 @default.
- W2022994460 hasConceptScore W2022994460C2522874641 @default.
- W2022994460 hasConceptScore W2022994460C2776178377 @default.
- W2022994460 hasConceptScore W2022994460C2776408679 @default.
- W2022994460 hasConceptScore W2022994460C2776461080 @default.
- W2022994460 hasConceptScore W2022994460C2776603314 @default.
- W2022994460 hasConceptScore W2022994460C2777003663 @default.
- W2022994460 hasConceptScore W2022994460C2777288759 @default.
- W2022994460 hasConceptScore W2022994460C2780040827 @default.
- W2022994460 hasConceptScore W2022994460C71924100 @default.
- W2022994460 hasConceptScore W2022994460C86803240 @default.
- W2022994460 hasConceptScore W2022994460C98274493 @default.
- W2022994460 hasIssue "5" @default.
- W2022994460 hasLocation W20229944601 @default.
- W2022994460 hasLocation W20229944602 @default.