FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022996508> ?p ?o ?g. }

• W2022996508 endingPage "161" @default.
• W2022996508 startingPage "151" @default.
• W2022996508 abstract "Under the new U.S. Environmental Protection Agency (EPA) Cancer Risk Assessment Guidelines [U.S. EPA, 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001B, March 2005], the quantitative model chosen for cancer risk assessment is based on the mode-of-action (MOA) of the chemical under consideration. In particular, the risk assessment model depends on whether or not the chemical causes tumors through a direct DNA-reactive mechanism. It is assumed that direct DNA-reactive carcinogens initiate carcinogenesis by inducing mutations and have low-dose linear dose–response curves, whereas carcinogens that operate through a nonmutagenic MOA may have nonlinear dose–responses. We are currently evaluating whether the analysis of in vivo gene mutation data can inform the risk assessment process by better defining the MOA for cancer and thus influencing the choice of the low-dose extrapolation model. This assessment includes both a temporal analysis of mutation induction and a dose–response concordance analysis of mutation with tumor incidence. Our analysis of published data on riddelliine in rats and dichloroacetic acid in mice indicates that our approach has merit. We propose an experimental design and graphical analysis that allow for assessing time-to-mutation and dose–response concordance, thereby optimizing the potential for in vivo mutation data to inform the choice of the quantitative model used in cancer risk assessment." @default.
• W2022996508 created "2016-06-24" @default.
• W2022996508 creator A5000257855 @default.
• W2022996508 creator A5021079697 @default.
• W2022996508 creator A5035119519 @default.
• W2022996508 creator A5052101010 @default.
• W2022996508 creator A5073266172 @default.
• W2022996508 creator A5078091393 @default.
• W2022996508 date "2008-07-01" @default.
• W2022996508 modified "2023-10-17" @default.
• W2022996508 title "Analysis of in vivo mutation data can inform cancer risk assessment" @default.
• W2022996508 cites W1966247675 @default.
• W2022996508 cites W1971344358 @default.
• W2022996508 cites W1979227629 @default.
• W2022996508 cites W1979822064 @default.
• W2022996508 cites W1999913271 @default.
• W2022996508 cites W2004820594 @default.
• W2022996508 cites W2009077052 @default.
• W2022996508 cites W2010245088 @default.
• W2022996508 cites W2016158172 @default.
• W2022996508 cites W2017258713 @default.
• W2022996508 cites W2025606236 @default.
• W2022996508 cites W2034269086 @default.
• W2022996508 cites W2045537135 @default.
• W2022996508 cites W2046024062 @default.
• W2022996508 cites W2047801896 @default.
• W2022996508 cites W2047941713 @default.
• W2022996508 cites W2053487215 @default.
• W2022996508 cites W2054405748 @default.
• W2022996508 cites W2061312078 @default.
• W2022996508 cites W2065409075 @default.
• W2022996508 cites W2076547880 @default.
• W2022996508 cites W2083879124 @default.
• W2022996508 cites W2085863145 @default.
• W2022996508 cites W2090285110 @default.
• W2022996508 cites W2098549869 @default.
• W2022996508 cites W2110207070 @default.
• W2022996508 cites W2111154757 @default.
• W2022996508 cites W2111423616 @default.
• W2022996508 cites W2115155704 @default.
• W2022996508 cites W2121669201 @default.
• W2022996508 cites W2132873473 @default.
• W2022996508 cites W2145010958 @default.
• W2022996508 cites W2155491988 @default.
• W2022996508 cites W4238573378 @default.
• W2022996508 doi "https://doi.org/10.1016/j.yrtph.2008.01.015" @default.
• W2022996508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18321622" @default.
• W2022996508 hasPublicationYear "2008" @default.
• W2022996508 type Work @default.
• W2022996508 sameAs 2022996508 @default.
• W2022996508 citedByCount "24" @default.
• W2022996508 countsByYear W20229965082012 @default.
• W2022996508 countsByYear W20229965082013 @default.
• W2022996508 countsByYear W20229965082014 @default.
• W2022996508 countsByYear W20229965082015 @default.
• W2022996508 countsByYear W20229965082017 @default.
• W2022996508 countsByYear W20229965082018 @default.
• W2022996508 countsByYear W20229965082019 @default.
• W2022996508 countsByYear W20229965082021 @default.
• W2022996508 countsByYear W20229965082023 @default.
• W2022996508 crossrefType "journal-article" @default.
• W2022996508 hasAuthorship W2022996508A5000257855 @default.
• W2022996508 hasAuthorship W2022996508A5021079697 @default.
• W2022996508 hasAuthorship W2022996508A5035119519 @default.
• W2022996508 hasAuthorship W2022996508A5052101010 @default.
• W2022996508 hasAuthorship W2022996508A5073266172 @default.
• W2022996508 hasAuthorship W2022996508A5078091393 @default.
• W2022996508 hasConcept C104317684 @default.
• W2022996508 hasConcept C112930515 @default.
• W2022996508 hasConcept C114246631 @default.
• W2022996508 hasConcept C121608353 @default.
• W2022996508 hasConcept C12174686 @default.
• W2022996508 hasConcept C160798450 @default.
• W2022996508 hasConcept C33070731 @default.
• W2022996508 hasConcept C38652104 @default.
• W2022996508 hasConcept C41008148 @default.
• W2022996508 hasConcept C501734568 @default.
• W2022996508 hasConcept C54355233 @default.
• W2022996508 hasConcept C555283112 @default.
• W2022996508 hasConcept C60644358 @default.
• W2022996508 hasConcept C70721500 @default.
• W2022996508 hasConcept C71924100 @default.
• W2022996508 hasConcept C86803240 @default.
• W2022996508 hasConceptScore W2022996508C104317684 @default.
• W2022996508 hasConceptScore W2022996508C112930515 @default.
• W2022996508 hasConceptScore W2022996508C114246631 @default.
• W2022996508 hasConceptScore W2022996508C121608353 @default.
• W2022996508 hasConceptScore W2022996508C12174686 @default.
• W2022996508 hasConceptScore W2022996508C160798450 @default.
• W2022996508 hasConceptScore W2022996508C33070731 @default.
• W2022996508 hasConceptScore W2022996508C38652104 @default.
• W2022996508 hasConceptScore W2022996508C41008148 @default.
• W2022996508 hasConceptScore W2022996508C501734568 @default.
• W2022996508 hasConceptScore W2022996508C54355233 @default.
• W2022996508 hasConceptScore W2022996508C555283112 @default.
• W2022996508 hasConceptScore W2022996508C60644358 @default.
• W2022996508 hasConceptScore W2022996508C70721500 @default.
• W2022996508 hasConceptScore W2022996508C71924100 @default.

• next