FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022996882> ?p ?o ?g. }

• W2022996882 endingPage "812" @default.
• W2022996882 startingPage "805" @default.
• W2022996882 abstract "Although transforming growth factor-beta s (TGF-beta s) are expressed widely in both adult and embryonic rat heart, both mRNA and protein expression increase following ischemic injury. Furthermore, exogenous administration of TGF-beta decreases cardiac damage following ischemia-reperfusion in rats. We have found that treatment of primary cultures of neonatal rat cardiomyocytes or cardiac fibroblasts with TGF-beta 1, 2, or 3 results in increased expression of TGF-beta 1, 2, and 3 mRNA. TGF-beta 2 was generally the least effective isoform in inducing TGF-beta expression. In cardiac fibroblasts mRNA expression of all TGF-beta s increased 2-3-fold following 1 h of treatment and decreased to control levels by 8 h which was accompanied by a 2.5- and 2.3-fold increase in TGF-beta 1 and 2 protein secretion, respectively. By 48 h of treatment mRNA levels for TGF-beta s 2 and 3 were less than 10% of control levels. In cardiomyocytes two-five-fold increases in mRNA levels were observed following 1-24 h of TGF-beta 1 treatment, but TGF-beta 1 and 3 mRNA levels returned to control values by 48 h while TGF-beta 2 mRNA expression remained elevated. TGF-beta 1 and 2 protein secreted by the cardiac myocytes was increased 2.9- and 1.7-fold, respectively. Autoinduction of TGF-beta s may play a beneficial role in cardiac wound healing by sustaining transient increases in TGF-beta levels from either endogenous synthesis or exogenous application." @default.
• W2022996882 created "2016-06-24" @default.
• W2022996882 creator A5000376423 @default.
• W2022996882 creator A5021536125 @default.
• W2022996882 creator A5042823571 @default.
• W2022996882 date "1995-02-01" @default.
• W2022996882 modified "2023-10-16" @default.
• W2022996882 title "Autoinduction of mRNA and protein expression for transforming growth factor-?s in cultured cardiac cells" @default.
• W2022996882 cites W1503388237 @default.
• W2022996882 cites W1561326647 @default.
• W2022996882 cites W1965586307 @default.
• W2022996882 cites W1972456273 @default.
• W2022996882 cites W1978694375 @default.
• W2022996882 cites W1993851092 @default.
• W2022996882 cites W2013993175 @default.
• W2022996882 cites W2035819392 @default.
• W2022996882 cites W2053352199 @default.
• W2022996882 cites W2056712858 @default.
• W2022996882 cites W2064566876 @default.
• W2022996882 cites W2073026500 @default.
• W2022996882 cites W2077969109 @default.
• W2022996882 cites W2088012334 @default.
• W2022996882 cites W2094695497 @default.
• W2022996882 cites W2117507292 @default.
• W2022996882 cites W2119491066 @default.
• W2022996882 cites W2129965949 @default.
• W2022996882 cites W2134812217 @default.
• W2022996882 cites W2136819827 @default.
• W2022996882 cites W2139336812 @default.
• W2022996882 cites W2159579113 @default.
• W2022996882 cites W2159774166 @default.
• W2022996882 cites W2163954552 @default.
• W2022996882 cites W2168476587 @default.
• W2022996882 cites W2172193595 @default.
• W2022996882 cites W2335838053 @default.
• W2022996882 cites W2346002398 @default.
• W2022996882 cites W2576734941 @default.
• W2022996882 cites W2519457089 @default.
• W2022996882 doi "https://doi.org/10.1016/0022-2828(95)90087-x" @default.
• W2022996882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7776387" @default.
• W2022996882 hasPublicationYear "1995" @default.
• W2022996882 type Work @default.
• W2022996882 sameAs 2022996882 @default.
• W2022996882 citedByCount "49" @default.
• W2022996882 countsByYear W20229968822012 @default.
• W2022996882 countsByYear W20229968822013 @default.
• W2022996882 countsByYear W20229968822014 @default.
• W2022996882 countsByYear W20229968822017 @default.
• W2022996882 countsByYear W20229968822018 @default.
• W2022996882 countsByYear W20229968822020 @default.
• W2022996882 countsByYear W20229968822021 @default.
• W2022996882 countsByYear W20229968822022 @default.
• W2022996882 crossrefType "journal-article" @default.
• W2022996882 hasAuthorship W2022996882A5000376423 @default.
• W2022996882 hasAuthorship W2022996882A5021536125 @default.
• W2022996882 hasAuthorship W2022996882A5042823571 @default.
• W2022996882 hasConcept C104317684 @default.
• W2022996882 hasConcept C105580179 @default.
• W2022996882 hasConcept C111001777 @default.
• W2022996882 hasConcept C118131993 @default.
• W2022996882 hasConcept C126322002 @default.
• W2022996882 hasConcept C134018914 @default.
• W2022996882 hasConcept C150194340 @default.
• W2022996882 hasConcept C185592680 @default.
• W2022996882 hasConcept C199360897 @default.
• W2022996882 hasConcept C2776174256 @default.
• W2022996882 hasConcept C2778229498 @default.
• W2022996882 hasConcept C41008148 @default.
• W2022996882 hasConcept C53345823 @default.
• W2022996882 hasConcept C55493867 @default.
• W2022996882 hasConcept C71924100 @default.
• W2022996882 hasConcept C86803240 @default.
• W2022996882 hasConceptScore W2022996882C104317684 @default.
• W2022996882 hasConceptScore W2022996882C105580179 @default.
• W2022996882 hasConceptScore W2022996882C111001777 @default.
• W2022996882 hasConceptScore W2022996882C118131993 @default.
• W2022996882 hasConceptScore W2022996882C126322002 @default.
• W2022996882 hasConceptScore W2022996882C134018914 @default.
• W2022996882 hasConceptScore W2022996882C150194340 @default.
• W2022996882 hasConceptScore W2022996882C185592680 @default.
• W2022996882 hasConceptScore W2022996882C199360897 @default.
• W2022996882 hasConceptScore W2022996882C2776174256 @default.
• W2022996882 hasConceptScore W2022996882C2778229498 @default.
• W2022996882 hasConceptScore W2022996882C41008148 @default.
• W2022996882 hasConceptScore W2022996882C53345823 @default.
• W2022996882 hasConceptScore W2022996882C55493867 @default.
• W2022996882 hasConceptScore W2022996882C71924100 @default.
• W2022996882 hasConceptScore W2022996882C86803240 @default.
• W2022996882 hasIssue "2" @default.
• W2022996882 hasLocation W20229968821 @default.
• W2022996882 hasLocation W20229968822 @default.
• W2022996882 hasOpenAccess W2022996882 @default.
• W2022996882 hasPrimaryLocation W20229968821 @default.
• W2022996882 hasRelatedWork W1503228526 @default.
• W2022996882 hasRelatedWork W1712086365 @default.
• W2022996882 hasRelatedWork W1980194808 @default.
• W2022996882 hasRelatedWork W2006113785 @default.
• W2022996882 hasRelatedWork W2016510087 @default.

• next