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- W2022997145 abstract "Synthetic somatostatin stimulated cyclic GMP accumulation with dose dependency (10 ng/ml – 10 μg/ml in a dose examined) in rat anterior pituitary gland in vitro. The stimulation of cyclic GMP levels in the gland was observed after 2 min incubation with somatostatin. Cyclic AMP production induced by TRH or PGE1 was supressed by this GH release inhibiting factor, while cyclic GMP concentration in the gland was elevated. The present results seem to suggest that inhibitory effect on GH release by somatostatin in anterior pituitary gland is mediated through change in concentration of cyclic AMP and cyclic GMP in the target cells." @default.
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- W2022997145 date "1974-11-01" @default.
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- W2022997145 title "Stimulation of guanosine 3′,5′-cyclic monophosphate accumulation in rat anterior pituitary gland in vitro by synthetic somatostatin" @default.
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- W2022997145 doi "https://doi.org/10.1016/0006-291x(74)90532-4" @default.
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