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• W2022998640 abstract "Abstract Objective To understand in detail the mechanisms of autoantibody production in patients with systemic lupus erythematosus (SLE), we performed a comprehensive analysis of the normal human immunoglobulin light chain V λ repertoire and compared it with the V λ repertoire in SLE patients. Methods The SLE V λ repertoire of B cells obtained from 3 SLE patients was analyzed and compared in detail with the V λ repertoire of IgM+ B cells obtained from 3 human fetal spleens and IgM+,CD5+ B cells obtained from 2 normal adults. Conventional IgM+,CD5– B cells obtained from normal adults were used as controls. V λ –J λ rearrangements were amplified from the genomic DNA of individual B cells by polymerase chain reaction. Results The expressed V λ repertoire of SLE patients contained several similarities with the expressed repertoire of the fetus and the adult CD5+ B cells. The V λ genes 3L and 1G were overexpressed in the fetus, the adult CD5+ B cells, and the patients with SLE. The selection for rearrangements with restricted junctional diversity by utilization of homology‐mediated joining, together with diminished N nucleotide addition, was a prominent feature of fetal, adult CD5+, and SLE B cell repertoires. Furthermore, profound expansion of V λ clones with identical third complementarity‐determining regions was observed in the adult CD5+, fetal, and SLE B cell repertoires. Notably, significant numbers of expanded adult CD5+ B cells, fetal, and SLE V λ clones utilized homology‐mediated joining at the V λ –J λ junctions. Conclusion These data demonstrate that the SLE V λ –J λ repertoire manifests characteristics of normal adult IgM+,CD5+ and fetal B cell populations that are known to be enriched for the production of natural autoantibodies." @default.
• W2022998640 created "2016-06-24" @default.
• W2022998640 creator A5019886336 @default.
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• W2022998640 date "2004-08-01" @default.
• W2022998640 modified "2023-10-12" @default.
• W2022998640 title "The V?-J? repertoire of patients with systemic lupus erythematosus manifests characteristics of the natural antibody repertoire" @default.
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• W2022998640 doi "https://doi.org/10.1002/art.20439" @default.
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