Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022998730> ?p ?o ?g. }
- W2022998730 endingPage "878" @default.
- W2022998730 startingPage "869" @default.
- W2022998730 abstract "People are very likely to start psychoactive drug use during adolescence, an earlier onset being associated with a higher risk of developing addiction later in life. In experiment I, Pre- (postnatal day (pnd) 23–35), Mid- (pnd 36–48), or Post- (pnd 49–61) adolescent mice underwent a restricted-drinking period (2 h/day for 12 days), one bottle containing water and the other containing nicotine (10 mg/l) or water. After this period, Mid-adolescents showed prominent exploration and reduced anxiety in the plus-maze. This ontogenetic profile was dampened by nicotine consumption. After 2 months, these mice were tested in a novel environment (30 min/day for 3 days). Locomotor-habituation profiles were specifically disrupted by nicotine consumption during Mid-adolescence, suggesting this age as a critical period. In experiment II, Mid-adolescent (pnd 35–44) and adult (pnd >70) mice were pretreated with nicotine (0, 0.03, 0.10, 0.30 mg/kg/day for 10 days). Acute nicotine administration had opposite effects on anxiety in adolescents and adults. At 2 months after pretreatment, we measured levels of AMPA GluR2/3 subunits, thought to be involved in the control of addictive behaviors. Nicotine exposure during Mid-adolescence dose-dependently downregulated these subunits in the striatum and hippocampus, but comparable exposure during adulthood had either opposite or no effects. NMDA NR2A/B subunits were affected by nicotine, but without age-related differences. The present data identified a nicotine-vulnerable age window, characterized by long-term disruption of locomotor habituation and downregulation of AMPA receptors. These findings support neurobiological vulnerability to drugs in adolescent humans." @default.
- W2022998730 created "2016-06-24" @default.
- W2022998730 creator A5007959343 @default.
- W2022998730 creator A5010093730 @default.
- W2022998730 creator A5013650042 @default.
- W2022998730 creator A5045316998 @default.
- W2022998730 creator A5074270662 @default.
- W2022998730 creator A5079401701 @default.
- W2022998730 date "2003-11-03" @default.
- W2022998730 modified "2023-10-12" @default.
- W2022998730 title "Behavioral and Neurochemical Vulnerability During Adolescence in Mice: Studies with Nicotine" @default.
- W2022998730 cites W1571140265 @default.
- W2022998730 cites W165780547 @default.
- W2022998730 cites W1964867272 @default.
- W2022998730 cites W1971303103 @default.
- W2022998730 cites W1974719375 @default.
- W2022998730 cites W1977207248 @default.
- W2022998730 cites W1978275630 @default.
- W2022998730 cites W1982556596 @default.
- W2022998730 cites W1985065786 @default.
- W2022998730 cites W1985645068 @default.
- W2022998730 cites W1987999125 @default.
- W2022998730 cites W1988659186 @default.
- W2022998730 cites W1994436062 @default.
- W2022998730 cites W1997994375 @default.
- W2022998730 cites W1998335883 @default.
- W2022998730 cites W1998924641 @default.
- W2022998730 cites W1999979314 @default.
- W2022998730 cites W2006999172 @default.
- W2022998730 cites W2007611402 @default.
- W2022998730 cites W2010102500 @default.
- W2022998730 cites W2018514933 @default.
- W2022998730 cites W2019260419 @default.
- W2022998730 cites W2019674734 @default.
- W2022998730 cites W2022247662 @default.
- W2022998730 cites W2027458270 @default.
- W2022998730 cites W2036213891 @default.
- W2022998730 cites W2039989651 @default.
- W2022998730 cites W2041527379 @default.
- W2022998730 cites W2045971161 @default.
- W2022998730 cites W2049796382 @default.
- W2022998730 cites W2059131332 @default.
- W2022998730 cites W2059208609 @default.
- W2022998730 cites W2059406298 @default.
- W2022998730 cites W2059991118 @default.
- W2022998730 cites W2062345330 @default.
- W2022998730 cites W2066371075 @default.
- W2022998730 cites W2075741245 @default.
- W2022998730 cites W2090762149 @default.
- W2022998730 cites W2092446825 @default.
- W2022998730 cites W2100579958 @default.
- W2022998730 cites W2112588374 @default.
- W2022998730 cites W2122592499 @default.
- W2022998730 cites W2130237886 @default.
- W2022998730 cites W2131366415 @default.
- W2022998730 cites W2135789331 @default.
- W2022998730 cites W2159655610 @default.
- W2022998730 cites W2161886949 @default.
- W2022998730 cites W2165810630 @default.
- W2022998730 cites W4244101447 @default.
- W2022998730 cites W4248526027 @default.
- W2022998730 cites W4312861385 @default.
- W2022998730 doi "https://doi.org/10.1038/sj.npp.1300366" @default.
- W2022998730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14666123" @default.
- W2022998730 hasPublicationYear "2003" @default.
- W2022998730 type Work @default.
- W2022998730 sameAs 2022998730 @default.
- W2022998730 citedByCount "140" @default.
- W2022998730 countsByYear W20229987302012 @default.
- W2022998730 countsByYear W20229987302013 @default.
- W2022998730 countsByYear W20229987302014 @default.
- W2022998730 countsByYear W20229987302015 @default.
- W2022998730 countsByYear W20229987302016 @default.
- W2022998730 countsByYear W20229987302017 @default.
- W2022998730 countsByYear W20229987302018 @default.
- W2022998730 countsByYear W20229987302019 @default.
- W2022998730 countsByYear W20229987302020 @default.
- W2022998730 countsByYear W20229987302021 @default.
- W2022998730 countsByYear W20229987302022 @default.
- W2022998730 countsByYear W20229987302023 @default.
- W2022998730 crossrefType "journal-article" @default.
- W2022998730 hasAuthorship W2022998730A5007959343 @default.
- W2022998730 hasAuthorship W2022998730A5010093730 @default.
- W2022998730 hasAuthorship W2022998730A5013650042 @default.
- W2022998730 hasAuthorship W2022998730A5045316998 @default.
- W2022998730 hasAuthorship W2022998730A5074270662 @default.
- W2022998730 hasAuthorship W2022998730A5079401701 @default.
- W2022998730 hasBestOaLocation W20229987301 @default.
- W2022998730 hasConcept C118552586 @default.
- W2022998730 hasConcept C126322002 @default.
- W2022998730 hasConcept C134018914 @default.
- W2022998730 hasConcept C15744967 @default.
- W2022998730 hasConcept C169760540 @default.
- W2022998730 hasConcept C25876315 @default.
- W2022998730 hasConcept C2779177420 @default.
- W2022998730 hasConcept C2779547902 @default.
- W2022998730 hasConcept C2780062018 @default.
- W2022998730 hasConcept C2781161787 @default.