FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023000147> ?p ?o ?g. }

• W2023000147 endingPage "e23530" @default.
• W2023000147 startingPage "e23530" @default.
• W2023000147 abstract "The early use of fresh frozen plasma as a resuscitative agent after hemorrhagic shock has been associated with improved survival, but the mechanism of protection is unknown. Hemorrhagic shock causes endothelial cell dysfunction and we hypothesized that fresh frozen plasma would restore endothelial integrity and reduce syndecan-1 shedding after hemorrhagic shock. A prospective, observational study in severely injured patients in hemorrhagic shock demonstrated significantly elevated levels of syndecan-1 (554±93 ng/ml) after injury, which decreased with resuscitation (187±36 ng/ml) but was elevated compared to normal donors (27±1 ng/ml). Three pro-inflammatory cytokines, interferon-γ, fractalkine, and interleukin-1β, negatively correlated while one anti-inflammatory cytokine, IL-10, positively correlated with shed syndecan-1. These cytokines all play an important role in maintaining endothelial integrity. An in vitro model of endothelial injury then specifically examined endothelial permeability after treatment with fresh frozen plasma orlactated Ringers. Shock or endothelial injury disrupted junctional integrity and increased permeability, which was improved with fresh frozen plasma, but not lactated Ringers. Changes in endothelial cell permeability correlated with syndecan-1 shedding. These data suggest that plasma based resuscitation preserved endothelial syndecan-1 and maintained endothelial integrity, and may help to explain the protective effects of fresh frozen plasma after hemorrhagic shock." @default.
• W2023000147 created "2016-06-24" @default.
• W2023000147 creator A5032275121 @default.
• W2023000147 creator A5040646685 @default.
• W2023000147 creator A5042251160 @default.
• W2023000147 creator A5047675054 @default.
• W2023000147 creator A5059650058 @default.
• W2023000147 creator A5065762407 @default.
• W2023000147 creator A5071697044 @default.
• W2023000147 creator A5073839964 @default.
• W2023000147 creator A5083470050 @default.
• W2023000147 creator A5087864618 @default.
• W2023000147 date "2011-08-19" @default.
• W2023000147 modified "2023-10-16" @default.
• W2023000147 title "Modulation of Syndecan-1 Shedding after Hemorrhagic Shock and Resuscitation" @default.
• W2023000147 cites W1547580946 @default.
• W2023000147 cites W1853047741 @default.
• W2023000147 cites W1904705252 @default.
• W2023000147 cites W1963709999 @default.
• W2023000147 cites W1975601614 @default.
• W2023000147 cites W1975962159 @default.
• W2023000147 cites W1986151431 @default.
• W2023000147 cites W1987361003 @default.
• W2023000147 cites W1991878197 @default.
• W2023000147 cites W1993143514 @default.
• W2023000147 cites W2008160848 @default.
• W2023000147 cites W2008669330 @default.
• W2023000147 cites W2011356417 @default.
• W2023000147 cites W2011748829 @default.
• W2023000147 cites W2012711792 @default.
• W2023000147 cites W2015918023 @default.
• W2023000147 cites W2016874822 @default.
• W2023000147 cites W2018680532 @default.
• W2023000147 cites W2024526916 @default.
• W2023000147 cites W2029880457 @default.
• W2023000147 cites W2040242558 @default.
• W2023000147 cites W2042109117 @default.
• W2023000147 cites W2044877583 @default.
• W2023000147 cites W2045365777 @default.
• W2023000147 cites W2046044305 @default.
• W2023000147 cites W2048828214 @default.
• W2023000147 cites W2049485757 @default.
• W2023000147 cites W2056471424 @default.
• W2023000147 cites W2060046595 @default.
• W2023000147 cites W2083005745 @default.
• W2023000147 cites W2084280207 @default.
• W2023000147 cites W2090650515 @default.
• W2023000147 cites W2091839917 @default.
• W2023000147 cites W2096942445 @default.
• W2023000147 cites W2105981152 @default.
• W2023000147 cites W2112613073 @default.
• W2023000147 cites W2128514908 @default.
• W2023000147 cites W2140760627 @default.
• W2023000147 cites W2142912738 @default.
• W2023000147 cites W2152252241 @default.
• W2023000147 cites W2157170589 @default.
• W2023000147 cites W2166283593 @default.
• W2023000147 doi "https://doi.org/10.1371/journal.pone.0023530" @default.
• W2023000147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3158765" @default.
• W2023000147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21886795" @default.
• W2023000147 hasPublicationYear "2011" @default.
• W2023000147 type Work @default.
• W2023000147 sameAs 2023000147 @default.
• W2023000147 citedByCount "165" @default.
• W2023000147 countsByYear W20230001472012 @default.
• W2023000147 countsByYear W20230001472013 @default.
• W2023000147 countsByYear W20230001472014 @default.
• W2023000147 countsByYear W20230001472015 @default.
• W2023000147 countsByYear W20230001472016 @default.
• W2023000147 countsByYear W20230001472017 @default.
• W2023000147 countsByYear W20230001472018 @default.
• W2023000147 countsByYear W20230001472019 @default.
• W2023000147 countsByYear W20230001472020 @default.
• W2023000147 countsByYear W20230001472021 @default.
• W2023000147 countsByYear W20230001472022 @default.
• W2023000147 countsByYear W20230001472023 @default.
• W2023000147 crossrefType "journal-article" @default.
• W2023000147 hasAuthorship W2023000147A5032275121 @default.
• W2023000147 hasAuthorship W2023000147A5040646685 @default.
• W2023000147 hasAuthorship W2023000147A5042251160 @default.
• W2023000147 hasAuthorship W2023000147A5047675054 @default.
• W2023000147 hasAuthorship W2023000147A5059650058 @default.
• W2023000147 hasAuthorship W2023000147A5065762407 @default.
• W2023000147 hasAuthorship W2023000147A5071697044 @default.
• W2023000147 hasAuthorship W2023000147A5073839964 @default.
• W2023000147 hasAuthorship W2023000147A5083470050 @default.
• W2023000147 hasAuthorship W2023000147A5087864618 @default.
• W2023000147 hasBestOaLocation W20230001471 @default.
• W2023000147 hasConcept C113045295 @default.
• W2023000147 hasConcept C123012128 @default.
• W2023000147 hasConcept C126322002 @default.
• W2023000147 hasConcept C1491633281 @default.
• W2023000147 hasConcept C16685009 @default.
• W2023000147 hasConcept C185592680 @default.
• W2023000147 hasConcept C202751555 @default.
• W2023000147 hasConcept C203014093 @default.
• W2023000147 hasConcept C2776246508 @default.
• W2023000147 hasConcept C2776914184 @default.

• next