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• W2023002339 endingPage "4194" @default.
• W2023002339 startingPage "4179" @default.
• W2023002339 abstract "Nucleocytoplasmic trafficking in eukaryotic cells is a highly regulated and coordinated process which involves an increasing variety of soluble nuclear transport receptors. Generally, transport receptors specifically bind their cargo and facilitate its transition through nuclear pore complexes, aqueous channels connecting the two compartments. Directionality of such transport events by receptors of the importin β superfamily requires the interaction with the small GTPase Ras-related nuclear antigen (Ran). While importins need RanGTP to release their cargo in the nucleus and thus to terminate import, exportins recruit cargo in the RanGTP-bound state. The exportin chromosome region maintenance 1 (CRM1) is a highly versatile transport receptor that exports a plethora of different protein and RNP cargoes. Moreover, binding of RanGTP and of cargo to CRM1 are highly cooperative events despite the fact that cargo and RanGTP do not interact directly in crystal structures of assembled export complexes. Integrative approaches have recently unraveled the individual steps of the CRM1 transport cycle at a structural level and explained how the HEAT-repeat architecture of CRM1 provides a framework for the key elements to mediate allosteric interactions with RanGTP, Ran binding proteins and cargo. Moreover, during the last decade, CRM1 has become a more and more appreciated target for anti-cancer drugs. Hence, detailed understanding of the flexibility, the regulatory features and the positive binding cooperativity between CRM1, Ran and cargo is a prerequisite for the development of highly effective drugs. Here we review recent structural advances in the characterization of CRM1 and CRM1-containing complexes with a special emphasis on X-ray crystallographic studies." @default.
• W2023002339 created "2016-06-24" @default.
• W2023002339 creator A5008795615 @default.
• W2023002339 creator A5065838297 @default.
• W2023002339 creator A5089962199 @default.
• W2023002339 date "2014-06-06" @default.
• W2023002339 modified "2023-09-27" @default.
• W2023002339 title "Allosteric control of the exportin<scp>CRM</scp>1 unraveled by crystal structure analysis" @default.
• W2023002339 cites W128196120 @default.
• W2023002339 cites W1503329918 @default.
• W2023002339 cites W1544054537 @default.
• W2023002339 cites W1549520851 @default.
• W2023002339 cites W1562998360 @default.
• W2023002339 cites W1594135844 @default.
• W2023002339 cites W1608820323 @default.
• W2023002339 cites W1675243257 @default.
• W2023002339 cites W1884072983 @default.
• W2023002339 cites W1904553979 @default.
• W2023002339 cites W1963705823 @default.
• W2023002339 cites W1968110789 @default.
• W2023002339 cites W1968863167 @default.
• W2023002339 cites W1971794652 @default.
• W2023002339 cites W1971961101 @default.
• W2023002339 cites W1973879755 @default.
• W2023002339 cites W1976172300 @default.
• W2023002339 cites W1976199526 @default.
• W2023002339 cites W1979451022 @default.
• W2023002339 cites W1980071750 @default.
• W2023002339 cites W1981243923 @default.
• W2023002339 cites W1981715749 @default.
• W2023002339 cites W1987019783 @default.
• W2023002339 cites W1987530377 @default.
• W2023002339 cites W1991018390 @default.
• W2023002339 cites W1993287040 @default.
• W2023002339 cites W1996313023 @default.
• W2023002339 cites W1997117872 @default.
• W2023002339 cites W1999081551 @default.
• W2023002339 cites W2001887737 @default.
• W2023002339 cites W2002245757 @default.
• W2023002339 cites W2003977276 @default.
• W2023002339 cites W2004004385 @default.
• W2023002339 cites W2007755820 @default.
• W2023002339 cites W2008922773 @default.
• W2023002339 cites W2009386327 @default.
• W2023002339 cites W2012218395 @default.
• W2023002339 cites W2013253155 @default.
• W2023002339 cites W2016153572 @default.
• W2023002339 cites W2022757531 @default.
• W2023002339 cites W2023079546 @default.
• W2023002339 cites W2026597179 @default.
• W2023002339 cites W2027202090 @default.
• W2023002339 cites W2028930390 @default.
• W2023002339 cites W2029003444 @default.
• W2023002339 cites W2029225125 @default.
• W2023002339 cites W2029690067 @default.
• W2023002339 cites W2032785100 @default.
• W2023002339 cites W2034577054 @default.
• W2023002339 cites W2038256325 @default.
• W2023002339 cites W2039208569 @default.
• W2023002339 cites W2043455507 @default.
• W2023002339 cites W2043843654 @default.
• W2023002339 cites W2046497407 @default.
• W2023002339 cites W2047245819 @default.
• W2023002339 cites W2049157126 @default.
• W2023002339 cites W2062233810 @default.
• W2023002339 cites W2063394866 @default.
• W2023002339 cites W2064370962 @default.
• W2023002339 cites W2066835429 @default.
• W2023002339 cites W2067415570 @default.
• W2023002339 cites W2072870129 @default.
• W2023002339 cites W2073109412 @default.
• W2023002339 cites W2076235195 @default.
• W2023002339 cites W2081713455 @default.
• W2023002339 cites W2082739624 @default.
• W2023002339 cites W2083964225 @default.
• W2023002339 cites W2099970679 @default.
• W2023002339 cites W2104580729 @default.
• W2023002339 cites W2105544978 @default.
• W2023002339 cites W2105554009 @default.
• W2023002339 cites W2106243159 @default.
• W2023002339 cites W2106925642 @default.
• W2023002339 cites W2108442683 @default.
• W2023002339 cites W2108482921 @default.
• W2023002339 cites W2109882555 @default.
• W2023002339 cites W2111166374 @default.
• W2023002339 cites W2114131857 @default.
• W2023002339 cites W2115943711 @default.
• W2023002339 cites W2119909859 @default.
• W2023002339 cites W2124354424 @default.
• W2023002339 cites W2126182028 @default.
• W2023002339 cites W2129328366 @default.
• W2023002339 cites W2134160801 @default.
• W2023002339 cites W2142496066 @default.
• W2023002339 cites W2146719608 @default.
• W2023002339 cites W2148718900 @default.
• W2023002339 cites W2154925328 @default.
• W2023002339 cites W2154975063 @default.
• W2023002339 cites W2155085170 @default.

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