FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023002433> ?p ?o ?g. }

• W2023002433 endingPage "904" @default.
• W2023002433 startingPage "901" @default.
• W2023002433 abstract "1. Protein kinase C (PKC) is a family of enzymes that is activated by diacylglycerol (DAG) following phospholipase (PL) C activation. Protein kinase C may also be activated by metabolites and arachidonic acid generated by breakdown of membrane phospholipids by PLD and PLA2, respectively. Subsequent to PKC activation, key protein substrates are phosphorylated, resulting in the facilitation of transmitter release. 2. Phorbol esters are compounds that mimic the actions of DAG on PKC and have been shown to facilitate stimulation-induced (S-I) transmitter release in rat brain. However, some phorbol esters that have a high affinity for PKC have no effect on transmitter release, whereas others with a lower affinity for PKC markedly elevate S-I transmitter release. 3. The structure and, more importantly, the lipophilicity of the phorbol esters determines their ability to access and activate the intraneuronal pools of PKC that are involved with transmitter release. In studies in which cell membranes were intact, phorbol esters did not display the characteristics expected based on their affinities for PKC in contrast with studies in disrupted synaptosomes. This supports the hypothesis that the membrane plays a critical role in determining the effects of phorbol esters on PKC. 4. B-50, a PKC substrate thought to be involved in transmitter release, also appears to be differentially phosphorylated by various phorbol esters. The effects on B-50 phosphorylation in intact synaptosomes, but not disrupted synaptosomes, are well correlated with the effects of phorbol esters on S-I transmitter release. 5. B-50 is colocalized with actin, which has also been suggested to play an important role in facilitating the movement of reserve pools of transmitter vesicles to the readily releasable state. Therefore, it is possible that the phosphorylation status of B-50 directly influences the organization of actin filaments, thereby allowing transmitter output to be sustained under high levels of stimulation." @default.
• W2023002433 created "2016-06-24" @default.
• W2023002433 creator A5029412174 @default.
• W2023002433 date "2001-11-01" @default.
• W2023002433 modified "2023-09-23" @default.
• W2023002433 title "Involvement Of B-50 (GAP-43) Phosphorylation In The Modulation Of Transmitter Release By Protein Kinase C" @default.
• W2023002433 cites W1002279830 @default.
• W2023002433 cites W1495423595 @default.
• W2023002433 cites W1605503269 @default.
• W2023002433 cites W1933897045 @default.
• W2023002433 cites W1966261568 @default.
• W2023002433 cites W1967230963 @default.
• W2023002433 cites W1974654773 @default.
• W2023002433 cites W1979734756 @default.
• W2023002433 cites W1981646620 @default.
• W2023002433 cites W2001625431 @default.
• W2023002433 cites W2003130852 @default.
• W2023002433 cites W2013539562 @default.
• W2023002433 cites W2015571904 @default.
• W2023002433 cites W2016477781 @default.
• W2023002433 cites W2017664520 @default.
• W2023002433 cites W2034480539 @default.
• W2023002433 cites W2036264640 @default.
• W2023002433 cites W2038021239 @default.
• W2023002433 cites W2042733728 @default.
• W2023002433 cites W2059471766 @default.
• W2023002433 cites W2063928717 @default.
• W2023002433 cites W2074555316 @default.
• W2023002433 cites W2078679345 @default.
• W2023002433 cites W2079097093 @default.
• W2023002433 cites W2099628115 @default.
• W2023002433 cites W2105953958 @default.
• W2023002433 cites W2132025143 @default.
• W2023002433 cites W2156967607 @default.
• W2023002433 cites W2157032417 @default.
• W2023002433 cites W2163421864 @default.
• W2023002433 cites W2182811708 @default.
• W2023002433 cites W4243160999 @default.
• W2023002433 doi "https://doi.org/10.1046/j.1440-1681.2001.03545.x" @default.
• W2023002433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11703393" @default.
• W2023002433 hasPublicationYear "2001" @default.
• W2023002433 type Work @default.
• W2023002433 sameAs 2023002433 @default.
• W2023002433 citedByCount "17" @default.
• W2023002433 countsByYear W20230024332013 @default.
• W2023002433 countsByYear W20230024332015 @default.
• W2023002433 crossrefType "journal-article" @default.
• W2023002433 hasAuthorship W2023002433A5029412174 @default.
• W2023002433 hasConcept C11960822 @default.
• W2023002433 hasConcept C12554922 @default.
• W2023002433 hasConcept C184235292 @default.
• W2023002433 hasConcept C185592680 @default.
• W2023002433 hasConcept C195794163 @default.
• W2023002433 hasConcept C2780043322 @default.
• W2023002433 hasConcept C36020004 @default.
• W2023002433 hasConcept C55493867 @default.
• W2023002433 hasConcept C86803240 @default.
• W2023002433 hasConcept C95444343 @default.
• W2023002433 hasConceptScore W2023002433C11960822 @default.
• W2023002433 hasConceptScore W2023002433C12554922 @default.
• W2023002433 hasConceptScore W2023002433C184235292 @default.
• W2023002433 hasConceptScore W2023002433C185592680 @default.
• W2023002433 hasConceptScore W2023002433C195794163 @default.
• W2023002433 hasConceptScore W2023002433C2780043322 @default.
• W2023002433 hasConceptScore W2023002433C36020004 @default.
• W2023002433 hasConceptScore W2023002433C55493867 @default.
• W2023002433 hasConceptScore W2023002433C86803240 @default.
• W2023002433 hasConceptScore W2023002433C95444343 @default.
• W2023002433 hasIssue "11" @default.
• W2023002433 hasLocation W20230024331 @default.
• W2023002433 hasLocation W20230024332 @default.
• W2023002433 hasOpenAccess W2023002433 @default.
• W2023002433 hasPrimaryLocation W20230024331 @default.
• W2023002433 hasRelatedWork W1522511811 @default.
• W2023002433 hasRelatedWork W1629261239 @default.
• W2023002433 hasRelatedWork W1985042912 @default.
• W2023002433 hasRelatedWork W1992547494 @default.
• W2023002433 hasRelatedWork W2014555925 @default.
• W2023002433 hasRelatedWork W2018878905 @default.
• W2023002433 hasRelatedWork W2082907094 @default.
• W2023002433 hasRelatedWork W2145994523 @default.
• W2023002433 hasRelatedWork W2433930077 @default.
• W2023002433 hasRelatedWork W2740389847 @default.
• W2023002433 hasVolume "28" @default.
• W2023002433 isParatext "false" @default.
• W2023002433 isRetracted "false" @default.
• W2023002433 magId "2023002433" @default.
• W2023002433 workType "article" @default.