FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023004141> ?p ?o ?g. }

• W2023004141 endingPage "e79" @default.
• W2023004141 startingPage "e79" @default.
• W2023004141 abstract "It is generally assumed that axons use action potentials (APs) to transmit information fast and reliably to synapses. Yet, the reliability of transmission along fibers below 0.5 μm diameter, such as cortical and cerebellar axons, is unknown. Using detailed models of rodent cortical and squid axons and stochastic simulations, we show how conduction along such thin axons is affected by the probabilistic nature of voltage-gated ion channels (channel noise). We identify four distinct effects that corrupt propagating spike trains in thin axons: spikes were added, deleted, jittered, or split into groups depending upon the temporal pattern of spikes. Additional APs may appear spontaneously; however, APs in general seldom fail (<1%). Spike timing is jittered on the order of milliseconds over distances of millimeters, as conduction velocity fluctuates in two ways. First, variability in the number of Na channels opening in the early rising phase of the AP cause propagation speed to fluctuate gradually. Second, a novel mode of AP propagation (stochastic microsaltatory conduction), where the AP leaps ahead toward spontaneously formed clusters of open Na channels, produces random discrete jumps in spike time reliability. The combined effect of these two mechanisms depends on the pattern of spikes. Our results show that axonal variability is a general problem and should be taken into account when considering both neural coding and the reliability of synaptic transmission in densely connected cortical networks, where small synapses are typically innervated by thin axons. In contrast we find that thicker axons above 0.5 μm diameter are reliable." @default.
• W2023004141 created "2016-06-24" @default.
• W2023004141 creator A5015972398 @default.
• W2023004141 creator A5023706999 @default.
• W2023004141 date "2007-05-04" @default.
• W2023004141 modified "2023-10-18" @default.
• W2023004141 title "Stochastic Simulations on the Reliability of Action Potential Propagation in Thin Axons" @default.
• W2023004141 cites W1524865348 @default.
• W2023004141 cites W1537267296 @default.
• W2023004141 cites W1603661052 @default.
• W2023004141 cites W1644749979 @default.
• W2023004141 cites W1673584506 @default.
• W2023004141 cites W1814363416 @default.
• W2023004141 cites W1967973114 @default.
• W2023004141 cites W1968495411 @default.
• W2023004141 cites W1969483526 @default.
• W2023004141 cites W1970499295 @default.
• W2023004141 cites W1972459374 @default.
• W2023004141 cites W1974683465 @default.
• W2023004141 cites W1983869623 @default.
• W2023004141 cites W1994326065 @default.
• W2023004141 cites W2012082631 @default.
• W2023004141 cites W2015255899 @default.
• W2023004141 cites W2019484205 @default.
• W2023004141 cites W2024159878 @default.
• W2023004141 cites W2028803857 @default.
• W2023004141 cites W2029320496 @default.
• W2023004141 cites W2029368426 @default.
• W2023004141 cites W2039804216 @default.
• W2023004141 cites W2052259942 @default.
• W2023004141 cites W2054224256 @default.
• W2023004141 cites W2060505504 @default.
• W2023004141 cites W2067327770 @default.
• W2023004141 cites W2081033522 @default.
• W2023004141 cites W2088155512 @default.
• W2023004141 cites W2105935234 @default.
• W2023004141 cites W2106760111 @default.
• W2023004141 cites W2109584604 @default.
• W2023004141 cites W2124398758 @default.
• W2023004141 cites W2130302656 @default.
• W2023004141 cites W2130305130 @default.
• W2023004141 cites W2133301037 @default.
• W2023004141 cites W2136153614 @default.
• W2023004141 cites W2145198020 @default.
• W2023004141 cites W2149618862 @default.
• W2023004141 cites W2149729560 @default.
• W2023004141 cites W2153730779 @default.
• W2023004141 cites W2162019295 @default.
• W2023004141 cites W2166946091 @default.
• W2023004141 cites W2172225359 @default.
• W2023004141 cites W2615152173 @default.
• W2023004141 doi "https://doi.org/10.1371/journal.pcbi.0030079" @default.
• W2023004141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1864994" @default.
• W2023004141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17480115" @default.
• W2023004141 hasPublicationYear "2007" @default.
• W2023004141 type Work @default.
• W2023004141 sameAs 2023004141 @default.
• W2023004141 citedByCount "133" @default.
• W2023004141 countsByYear W20230041412012 @default.
• W2023004141 countsByYear W20230041412013 @default.
• W2023004141 countsByYear W20230041412014 @default.
• W2023004141 countsByYear W20230041412015 @default.
• W2023004141 countsByYear W20230041412016 @default.
• W2023004141 countsByYear W20230041412017 @default.
• W2023004141 countsByYear W20230041412018 @default.
• W2023004141 countsByYear W20230041412019 @default.
• W2023004141 countsByYear W20230041412020 @default.
• W2023004141 countsByYear W20230041412021 @default.
• W2023004141 countsByYear W20230041412022 @default.
• W2023004141 countsByYear W20230041412023 @default.
• W2023004141 crossrefType "journal-article" @default.
• W2023004141 hasAuthorship W2023004141A5015972398 @default.
• W2023004141 hasAuthorship W2023004141A5023706999 @default.
• W2023004141 hasBestOaLocation W20230041411 @default.
• W2023004141 hasConcept C115903868 @default.
• W2023004141 hasConcept C121332964 @default.
• W2023004141 hasConcept C12554922 @default.
• W2023004141 hasConcept C169760540 @default.
• W2023004141 hasConcept C178790620 @default.
• W2023004141 hasConcept C185263204 @default.
• W2023004141 hasConcept C185592680 @default.
• W2023004141 hasConcept C186060115 @default.
• W2023004141 hasConcept C195221683 @default.
• W2023004141 hasConcept C2779530196 @default.
• W2023004141 hasConcept C2781390188 @default.
• W2023004141 hasConcept C41008148 @default.
• W2023004141 hasConcept C50952357 @default.
• W2023004141 hasConcept C537181965 @default.
• W2023004141 hasConcept C54407271 @default.
• W2023004141 hasConcept C86803240 @default.
• W2023004141 hasConceptScore W2023004141C115903868 @default.
• W2023004141 hasConceptScore W2023004141C121332964 @default.
• W2023004141 hasConceptScore W2023004141C12554922 @default.
• W2023004141 hasConceptScore W2023004141C169760540 @default.
• W2023004141 hasConceptScore W2023004141C178790620 @default.
• W2023004141 hasConceptScore W2023004141C185263204 @default.
• W2023004141 hasConceptScore W2023004141C185592680 @default.
• W2023004141 hasConceptScore W2023004141C186060115 @default.

• next