FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023004351> ?p ?o ?g. }

• W2023004351 endingPage "85" @default.
• W2023004351 startingPage "78" @default.
• W2023004351 abstract "Hwaeumjeon is a classical prescription that has been traditionally used for treatment of urogenital diseases with no scientific evidences until now. Thus, the present study was performed to evaluate antitumor mechanism of ethanolic Hwaeumjeon (EHEJ). 2-Dimensional electrophoresis (2-DE) proteomic analysis, cell culture study, and Western blotting on apoptosis and prostate-specific antigen (PSA) related proteins were carried out in LNCaP prostate cancer cells. Eight spots with significant increased or decreased expression revealed by 2-DE based comparative proteomic analysis were identified as an increased protein ENC-1AS, four decreased proteins such as RAB34, SFRS1, heat shock 27, and proteasome activator, and three novel proteins such as Rho GDP dissociation inhibitor alpha, cytoplasmic antiproteinase, and EIF3EIP protein in EHEJ-treated LNCaP cells. In addition, EHEJ selectively inhibited the growth of LNCaP prostate cancer cells compared to normal human umbilical vein endothelial cells. Furthermore, EHEJ inhibited PSA and androgen receptor (AR) expression in androgen sensitive LNCaP prostate cancer cells at nontoxic concentrations. Also, EHEJ increased sub-G1 apoptotic portion, activated caspase-9 and -3, cleaved poly (ADP-ribose) polymerase (PARP) and increased the ratio of Bax to Bcl-2. Interestingly, EHEJ also attenuated phosphatidylinositol-3 kinase (PI3K) expression and suppressed the phosphorylation of survival gene AKT, ERK, and HSP27 in LNCaP cells. Consistently, PI3K and ERK inhibitors potentiated EHEJ-induced cytotoxicity and overexpression of Bcl-2 attenuated EHEJ-mediated apoptosis in LNCaP cells. These findings suggest that EHEJ induces mitochondrial dependent apoptosis partly via PI3K/AKT/HSP27/ERK pathways and inhibits PSA and AR in LNCaP cells as a prostate cancer chemopreventive candidate." @default.
• W2023004351 created "2016-06-24" @default.
• W2023004351 creator A5004812097 @default.
• W2023004351 creator A5020990780 @default.
• W2023004351 creator A5024239495 @default.
• W2023004351 creator A5029484493 @default.
• W2023004351 creator A5036196852 @default.
• W2023004351 creator A5037236595 @default.
• W2023004351 creator A5058522320 @default.
• W2023004351 creator A5062627428 @default.
• W2023004351 creator A5069167592 @default.
• W2023004351 creator A5073941367 @default.
• W2023004351 creator A5081984406 @default.
• W2023004351 creator A5083570047 @default.
• W2023004351 creator A5085325833 @default.
• W2023004351 date "2009-07-01" @default.
• W2023004351 modified "2023-10-15" @default.
• W2023004351 title "Ethanolic Hwaeumjeon induces mitochondrial dependent apoptosis partly via PI3K/AKT/HSP27/ERK pathways and inhibits PSA and AR in LNCaP cells" @default.
• W2023004351 cites W1606051673 @default.
• W2023004351 cites W1902714657 @default.
• W2023004351 cites W1988420272 @default.
• W2023004351 cites W1989120365 @default.
• W2023004351 cites W1993816595 @default.
• W2023004351 cites W2031646904 @default.
• W2023004351 cites W2031687428 @default.
• W2023004351 cites W2036324000 @default.
• W2023004351 cites W2040618631 @default.
• W2023004351 cites W2040770657 @default.
• W2023004351 cites W2047990617 @default.
• W2023004351 cites W2051122069 @default.
• W2023004351 cites W2074451679 @default.
• W2023004351 cites W2078594804 @default.
• W2023004351 cites W2079273110 @default.
• W2023004351 cites W2091164732 @default.
• W2023004351 cites W2093531170 @default.
• W2023004351 cites W2108739789 @default.
• W2023004351 cites W2115023106 @default.
• W2023004351 cites W2125988618 @default.
• W2023004351 cites W2126326024 @default.
• W2023004351 cites W2138178697 @default.
• W2023004351 cites W2140735579 @default.
• W2023004351 cites W2151501496 @default.
• W2023004351 cites W2154490707 @default.
• W2023004351 cites W2157603347 @default.
• W2023004351 cites W4233030758 @default.
• W2023004351 cites W4246407648 @default.
• W2023004351 cites W4251397350 @default.
• W2023004351 cites W4293247451 @default.
• W2023004351 cites W85465741 @default.
• W2023004351 doi "https://doi.org/10.1016/j.etap.2009.02.008" @default.
• W2023004351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21783985" @default.
• W2023004351 hasPublicationYear "2009" @default.
• W2023004351 type Work @default.
• W2023004351 sameAs 2023004351 @default.
• W2023004351 citedByCount "3" @default.
• W2023004351 countsByYear W20230043512019 @default.
• W2023004351 countsByYear W20230043512022 @default.
• W2023004351 crossrefType "journal-article" @default.
• W2023004351 hasAuthorship W2023004351A5004812097 @default.
• W2023004351 hasAuthorship W2023004351A5020990780 @default.
• W2023004351 hasAuthorship W2023004351A5024239495 @default.
• W2023004351 hasAuthorship W2023004351A5029484493 @default.
• W2023004351 hasAuthorship W2023004351A5036196852 @default.
• W2023004351 hasAuthorship W2023004351A5037236595 @default.
• W2023004351 hasAuthorship W2023004351A5058522320 @default.
• W2023004351 hasAuthorship W2023004351A5062627428 @default.
• W2023004351 hasAuthorship W2023004351A5069167592 @default.
• W2023004351 hasAuthorship W2023004351A5073941367 @default.
• W2023004351 hasAuthorship W2023004351A5081984406 @default.
• W2023004351 hasAuthorship W2023004351A5083570047 @default.
• W2023004351 hasAuthorship W2023004351A5085325833 @default.
• W2023004351 hasConcept C104317684 @default.
• W2023004351 hasConcept C121608353 @default.
• W2023004351 hasConcept C153911025 @default.
• W2023004351 hasConcept C184235292 @default.
• W2023004351 hasConcept C185592680 @default.
• W2023004351 hasConcept C190283241 @default.
• W2023004351 hasConcept C205260736 @default.
• W2023004351 hasConcept C2779559962 @default.
• W2023004351 hasConcept C2779723316 @default.
• W2023004351 hasConcept C502942594 @default.
• W2023004351 hasConcept C54355233 @default.
• W2023004351 hasConcept C55493867 @default.
• W2023004351 hasConcept C57074206 @default.
• W2023004351 hasConcept C68991219 @default.
• W2023004351 hasConcept C75217442 @default.
• W2023004351 hasConcept C86554907 @default.
• W2023004351 hasConcept C86803240 @default.
• W2023004351 hasConcept C95444343 @default.
• W2023004351 hasConcept C96232424 @default.
• W2023004351 hasConceptScore W2023004351C104317684 @default.
• W2023004351 hasConceptScore W2023004351C121608353 @default.
• W2023004351 hasConceptScore W2023004351C153911025 @default.
• W2023004351 hasConceptScore W2023004351C184235292 @default.
• W2023004351 hasConceptScore W2023004351C185592680 @default.
• W2023004351 hasConceptScore W2023004351C190283241 @default.
• W2023004351 hasConceptScore W2023004351C205260736 @default.
• W2023004351 hasConceptScore W2023004351C2779559962 @default.

• next