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• W2023004669 abstract "Both (+)- and (−)-4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)-vinyl]phenyl}ethyl)thio]methyl}benzoic acid (1), Thromboxane A2 and Leukotriene D4 receptor dual antagonist were synthesized. Racemic methyl 4-({[2-amino-1-(3-hydroxymethylphenyl)ethyl]thio}methyl)benzoate (2), and methyl 4-[({2-amino-1-[3-(1,3-dioxolan-2-yl)phenyl]ethyl}thio)methyl]benzoate (3) were derived from 2-(3-bromophenyl)-1,3-dioxolane (4). Compound 2 was resolved via di-p-toluoyl-D/L-tartaric acid salts to transform to (+)- and (−)-1, respectively. We also demonstrated that one optically active salt of compound 2 was converted to optically active (+)-1 without chromatography purification." @default.
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• W2023004669 date "2014-01-15" @default.
• W2023004669 modified "2023-09-26" @default.
• W2023004669 title "Synthesis of Optically Active Thromboxane A2 and Leukotriene D4 Receptor Antagonists" @default.
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• W2023004669 doi "https://doi.org/10.1246/bcsj.20130261" @default.
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