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- W2023005077 abstract "Although cellular RNA is subjected to the same oxidative insults as DNA and other cellular macromolecules, oxidative damage to RNA has not been a major focus in investigations of the biological consequences of free radical damage. In fact, because it is largely single-stranded and its bases lack the protection of hydrogen bonding and binding by specific proteins, RNA may be more susceptible to oxidative insults than is DNA. Oxidative damage to protein-coding RNA or non-coding RNA will, in turn, potentially cause errors in proteins and/or dysregulation of gene expression. While less lethal than mutations in the genome, such sublethal insults to cells might be associated with underlying mechanisms of several chronic diseases, including neurodegenerative disease. Recently, oxidative RNA damage has been described in several neurodegenerative diseases including Alzheimer disease, Parkinson disease, dementia with Lewy bodies, and prion diseases. Of particular interest, oxidative RNA damage can be demonstrated in vulnerable neurons early in disease, suggesting that RNA oxidation may actively contribute to the onset of the disease. An increasing body of evidence suggests that, mechanistically speaking, the detrimental effects of oxidative RNA damage to protein synthesis are attenuated, at least in part, by the existence of protective mechanisms that prevent the incorporation of the damaged ribonucleotides into the translational machinery. Further investigations aimed at understanding the processing mechanisms related to oxidative RNA damage and its consequences may provide significant insights into the pathogenesis of neurodegenerative and other degenerative diseases and lead to better therapeutic strategies." @default.
- W2023005077 created "2016-06-24" @default.
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- W2023005077 date "2008-05-20" @default.
- W2023005077 modified "2023-10-15" @default.
- W2023005077 title "Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease" @default.
- W2023005077 cites W1222036190 @default.
- W2023005077 cites W1489882701 @default.
- W2023005077 cites W1497413374 @default.
- W2023005077 cites W1534341660 @default.
- W2023005077 cites W1542215809 @default.
- W2023005077 cites W1551806602 @default.
- W2023005077 cites W1557154246 @default.
- W2023005077 cites W16268762 @default.
- W2023005077 cites W1650131236 @default.
- W2023005077 cites W1752358945 @default.
- W2023005077 cites W1848907877 @default.
- W2023005077 cites W1896970469 @default.
- W2023005077 cites W1969995127 @default.
- W2023005077 cites W1970452249 @default.
- W2023005077 cites W1970700352 @default.
- W2023005077 cites W1973130216 @default.
- W2023005077 cites W1974200504 @default.
- W2023005077 cites W1979101450 @default.
- W2023005077 cites W1979386519 @default.
- W2023005077 cites W1980742722 @default.
- W2023005077 cites W1981327924 @default.
- W2023005077 cites W1983255679 @default.
- W2023005077 cites W1983550639 @default.
- W2023005077 cites W1985001624 @default.
- W2023005077 cites W1985842394 @default.
- W2023005077 cites W1993250284 @default.
- W2023005077 cites W1993383247 @default.
- W2023005077 cites W1995186464 @default.
- W2023005077 cites W1995202749 @default.
- W2023005077 cites W2005875123 @default.
- W2023005077 cites W2006165112 @default.
- W2023005077 cites W2008012869 @default.
- W2023005077 cites W2008421184 @default.
- W2023005077 cites W2010055022 @default.
- W2023005077 cites W2010717664 @default.
- W2023005077 cites W2011352254 @default.
- W2023005077 cites W2011727503 @default.
- W2023005077 cites W2015236261 @default.
- W2023005077 cites W2016293448 @default.
- W2023005077 cites W2017422058 @default.
- W2023005077 cites W2019301423 @default.
- W2023005077 cites W2019369653 @default.
- W2023005077 cites W2026608449 @default.
- W2023005077 cites W2027751507 @default.
- W2023005077 cites W2028976892 @default.
- W2023005077 cites W2031904885 @default.
- W2023005077 cites W2031924680 @default.
- W2023005077 cites W2032929633 @default.
- W2023005077 cites W2034141196 @default.
- W2023005077 cites W2034574233 @default.
- W2023005077 cites W2038557175 @default.
- W2023005077 cites W2039630974 @default.
- W2023005077 cites W2041985732 @default.
- W2023005077 cites W2044627978 @default.
- W2023005077 cites W2047721309 @default.
- W2023005077 cites W2048446704 @default.
- W2023005077 cites W2048897966 @default.
- W2023005077 cites W2049368051 @default.
- W2023005077 cites W2051672316 @default.
- W2023005077 cites W2053138652 @default.
- W2023005077 cites W2054382152 @default.
- W2023005077 cites W2055308573 @default.
- W2023005077 cites W2057577552 @default.
- W2023005077 cites W2059334739 @default.
- W2023005077 cites W2061500679 @default.
- W2023005077 cites W2062431237 @default.
- W2023005077 cites W2062470263 @default.
- W2023005077 cites W2065129644 @default.
- W2023005077 cites W2066392481 @default.
- W2023005077 cites W2067623278 @default.
- W2023005077 cites W2067702215 @default.
- W2023005077 cites W2068113850 @default.
- W2023005077 cites W2069734695 @default.
- W2023005077 cites W2069787626 @default.
- W2023005077 cites W2071955212 @default.
- W2023005077 cites W2073675385 @default.
- W2023005077 cites W2077007523 @default.
- W2023005077 cites W2077161253 @default.
- W2023005077 cites W2078089123 @default.
- W2023005077 cites W2078670034 @default.
- W2023005077 cites W2079619202 @default.
- W2023005077 cites W2080423220 @default.
- W2023005077 cites W2081735872 @default.
- W2023005077 cites W2082702530 @default.
- W2023005077 cites W2087739128 @default.
- W2023005077 cites W2091404872 @default.