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• W2023005404 abstract "BackgroundPolar ejection forces have often been hypothesized to guide directional instability of mitotic chromosomes, but a direct link has never been established. This has led, in part, to the resurgence of alternative theories. By taking advantage of extremely precise femtosecond pulsed laser microsurgery, we abruptly alter the magnitude of polar ejection forces by severing vertebrate chromosome arms.ResultsReduction of polar ejection forces increases the amplitude of directional instability without altering other characteristics, thus establishing a direct link between polar ejection forces and the direction of chromosome movements. We find that polar ejection forces limit the range of chromosome oscillations by increasing the probability that motors at a leading kinetochore abruptly disengage or turn off, leading to a direction reversal.ConclusionsFrom the relation between the change in oscillation amplitude and the amount a chromosome arm is shortened, we are able to map the distribution of polar ejection forces across the spindle, which is surprisingly different from previously assumed distributions. These results allow us to differentiate between the mechanisms proposed to underlie the directional instability of chromosomes." @default.
• W2023005404 created "2016-06-24" @default.
• W2023005404 creator A5008831461 @default.
• W2023005404 creator A5044939488 @default.
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• W2023005404 date "2009-05-01" @default.
• W2023005404 modified "2023-10-17" @default.
• W2023005404 title "The Distribution of Polar Ejection Forces Determines the Amplitude of Chromosome Directional Instability" @default.
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• W2023005404 doi "https://doi.org/10.1016/j.cub.2009.04.036" @default.
• W2023005404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2712573" @default.
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