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• W2023006235 abstract "This manuscript examines the origins and nature of the function-derived activation detected by magnetic resonance imaging at ultrahigh fields using different encoding methods. A series of preclinical high field (7 T) and ultra-high field (17.2 T) fMRI experiments were performed using gradient echo EPI, spin echo EPI and spatio-temporally encoded (SPEN) strategies. The dependencies of the fMRI signal change on the strength of the magnetic field and on different acquisition and sequence parameters were investigated. Artifact-free rat brain images with good resolution in all areas, as well as significant localized activation maps upon forepaw stimulation, were obtained in a single scan using fully refocused SPEN sequences devoid of T2* effects. Our results showed that, besides the normal T2-weighted BOLD contribution that arises in spin-echo sequences, fMRI SPEN signals contain a strong component caused by apparent T1-related effects, demonstrating the potential of such technique for exploring functional activation in rodents and on humans at ultrahigh fields." @default.
• W2023006235 created "2016-06-24" @default.
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• W2023006235 date "2015-06-01" @default.
• W2023006235 modified "2023-10-16" @default.
• W2023006235 title "fMRI contrast at high and ultrahigh magnetic fields: Insight from complementary methods" @default.
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• W2023006235 doi "https://doi.org/10.1016/j.neuroimage.2015.03.018" @default.
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