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- W2023006652 abstract "Summary: A simple, rapid, and accurate high-performance liquid chromatographic method using fluorescence detection is described for the measurement of ciprofloxacin in plasma, whole blood, and erythrocytes. Ciprofloxacin and the internal standard difloxacin were separated on a μ-Bondapak C18 column (30 cm x 3.9 mm inside diameter, 10 μm particle size), using a mobile phase of 0.1 M phosphate buffer (pH 2.5):acetonitrile (75:25, vol/vol). The retention times were 5.1 min for ciprofloxacin and 7.9 min for difloxacin. The compounds were extracted from the three biological fluids using protein precipitation followed by a single-step liquid-liquid extraction. The assay is precise, with interassay coefficients of variation of ≥9.1% and an accuracy of ≥7.4% at 0.5 and 5.0 μg/ml (n = 5). The mean extraction recoveries of ciprofloxacin in plasma, whole blood, and erythrocytes were 84.4, 63.9, and 48.0%. The limit of detection for ciprofloxacin is 25 ng/ml. Ciprofloxacin concentrations in the three biological fluids were measured in patients with uncomplicated falciparum malaria to demonstrate the application of the method." @default.
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- W2023006652 date "1991-05-01" @default.
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- W2023006652 title "Measurement of Ciprofloxacin in Human Plasma, Whole Blood, and Erythrocytes by High-Performance Liquid Chromatography" @default.
- W2023006652 doi "https://doi.org/10.1097/00007691-199105000-00014" @default.
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