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- W2023007535 abstract "We demonstrate for the first time the detection of the folding state of double-stranded DNA in nanocapillaries with the resistive pulse technique. We show that glass capillaries can be pulled into nanocapillaries with diameters down to 45 nm. We study translocation of λ -DNA which is driven by an electrophoretic force through the nanocapillary. The resulting change in ionic current indicates the folding state of single λ -DNA molecules. Our experiments prove that nanocapillaries are suitable for label-free analysis of DNA in aqueous solutions and viable alternatives to solid-state nanopores made by silicon nanotechnology." @default.
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- W2023007535 date "2010-06-01" @default.
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- W2023007535 title "Detecting DNA Folding with Nanocapillaries" @default.
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- W2023007535 doi "https://doi.org/10.1021/nl100997s" @default.
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