Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023008235> ?p ?o ?g. }
- W2023008235 abstract "ABSTRACT: The ethanolic extract of Prunus mume (EPM) is a novel polyphenol preparation derived from branches (with leaves) of Prunus mume , which could be used as a functional ingredient for antioxidant and antiobesity therapy. The purpose of this study was to evaluate the safety of EPM. An EPM was prepared and evaluated for oral acute and subacute toxicity in Sprague–Dawley rats, while its mutagenic potential was assessed by a reverse mutation test using Salmonella typhimurium , by a bone marrow cell micronucleus test using ICR mice, and by a sperm abnormality test using ICR mice. The results showed no acute lethal effects at the maximal tested EPM dose of 20 g/kg bw in either rats or mice, suggesting that EPM can be regarded as virtually nontoxic. Administration at levels of 0.84, 1.67, and 3.33 g/kg bw to rats for 30 d did not induce any significant hematological, clinical, chemical, or histopathological changes. No mutagenicity evidence was detected in any of the 3 mutagenic tests. The level of “no observed adverse effect” (NOAEL) for EPM was above 3.33 g/kg bw for the subacute toxicity study." @default.
- W2023008235 created "2016-06-24" @default.
- W2023008235 creator A5015057508 @default.
- W2023008235 creator A5037128836 @default.
- W2023008235 creator A5050271009 @default.
- W2023008235 creator A5059448943 @default.
- W2023008235 creator A5065324700 @default.
- W2023008235 date "2009-11-01" @default.
- W2023008235 modified "2023-10-16" @default.
- W2023008235 title "Mutagenicity and Safety Evaluation of Ethanolic Extract of <i>Prunus mume</i>" @default.
- W2023008235 cites W1972097754 @default.
- W2023008235 cites W1973195696 @default.
- W2023008235 cites W1973337372 @default.
- W2023008235 cites W1980706506 @default.
- W2023008235 cites W1993776850 @default.
- W2023008235 cites W1995363132 @default.
- W2023008235 cites W1999535899 @default.
- W2023008235 cites W2004064701 @default.
- W2023008235 cites W2005156172 @default.
- W2023008235 cites W2011279163 @default.
- W2023008235 cites W2021277786 @default.
- W2023008235 cites W2030340778 @default.
- W2023008235 cites W2043994556 @default.
- W2023008235 cites W2048194502 @default.
- W2023008235 cites W2064965486 @default.
- W2023008235 cites W2067201805 @default.
- W2023008235 cites W2103369957 @default.
- W2023008235 cites W2158339900 @default.
- W2023008235 doi "https://doi.org/10.1111/j.1750-3841.2009.01372.x" @default.
- W2023008235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20492134" @default.
- W2023008235 hasPublicationYear "2009" @default.
- W2023008235 type Work @default.
- W2023008235 sameAs 2023008235 @default.
- W2023008235 citedByCount "11" @default.
- W2023008235 countsByYear W20230082352012 @default.
- W2023008235 countsByYear W20230082352014 @default.
- W2023008235 countsByYear W20230082352015 @default.
- W2023008235 countsByYear W20230082352016 @default.
- W2023008235 countsByYear W20230082352017 @default.
- W2023008235 countsByYear W20230082352019 @default.
- W2023008235 countsByYear W20230082352020 @default.
- W2023008235 countsByYear W20230082352021 @default.
- W2023008235 countsByYear W20230082352022 @default.
- W2023008235 crossrefType "journal-article" @default.
- W2023008235 hasAuthorship W2023008235A5015057508 @default.
- W2023008235 hasAuthorship W2023008235A5037128836 @default.
- W2023008235 hasAuthorship W2023008235A5050271009 @default.
- W2023008235 hasAuthorship W2023008235A5059448943 @default.
- W2023008235 hasAuthorship W2023008235A5065324700 @default.
- W2023008235 hasConcept C116263406 @default.
- W2023008235 hasConcept C117632636 @default.
- W2023008235 hasConcept C178790620 @default.
- W2023008235 hasConcept C185592680 @default.
- W2023008235 hasConcept C2778004101 @default.
- W2023008235 hasConcept C2781065037 @default.
- W2023008235 hasConcept C29730261 @default.
- W2023008235 hasConcept C36681516 @default.
- W2023008235 hasConcept C45080847 @default.
- W2023008235 hasConcept C523546767 @default.
- W2023008235 hasConcept C54355233 @default.
- W2023008235 hasConcept C55493867 @default.
- W2023008235 hasConcept C556039675 @default.
- W2023008235 hasConcept C70899900 @default.
- W2023008235 hasConcept C71924100 @default.
- W2023008235 hasConcept C86803240 @default.
- W2023008235 hasConcept C98274493 @default.
- W2023008235 hasConceptScore W2023008235C116263406 @default.
- W2023008235 hasConceptScore W2023008235C117632636 @default.
- W2023008235 hasConceptScore W2023008235C178790620 @default.
- W2023008235 hasConceptScore W2023008235C185592680 @default.
- W2023008235 hasConceptScore W2023008235C2778004101 @default.
- W2023008235 hasConceptScore W2023008235C2781065037 @default.
- W2023008235 hasConceptScore W2023008235C29730261 @default.
- W2023008235 hasConceptScore W2023008235C36681516 @default.
- W2023008235 hasConceptScore W2023008235C45080847 @default.
- W2023008235 hasConceptScore W2023008235C523546767 @default.
- W2023008235 hasConceptScore W2023008235C54355233 @default.
- W2023008235 hasConceptScore W2023008235C55493867 @default.
- W2023008235 hasConceptScore W2023008235C556039675 @default.
- W2023008235 hasConceptScore W2023008235C70899900 @default.
- W2023008235 hasConceptScore W2023008235C71924100 @default.
- W2023008235 hasConceptScore W2023008235C86803240 @default.
- W2023008235 hasConceptScore W2023008235C98274493 @default.
- W2023008235 hasIssue "9" @default.
- W2023008235 hasLocation W20230082351 @default.
- W2023008235 hasLocation W20230082352 @default.
- W2023008235 hasOpenAccess W2023008235 @default.
- W2023008235 hasPrimaryLocation W20230082351 @default.
- W2023008235 hasRelatedWork W146476749 @default.
- W2023008235 hasRelatedWork W1983701042 @default.
- W2023008235 hasRelatedWork W1984082042 @default.
- W2023008235 hasRelatedWork W2004064160 @default.
- W2023008235 hasRelatedWork W2030573484 @default.
- W2023008235 hasRelatedWork W2048627720 @default.
- W2023008235 hasRelatedWork W2345575539 @default.
- W2023008235 hasRelatedWork W2357952934 @default.
- W2023008235 hasRelatedWork W2360809063 @default.
- W2023008235 hasRelatedWork W4312238287 @default.
- W2023008235 hasVolume "74" @default.
- W2023008235 isParatext "false" @default.