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- W202301088 abstract "THIOL-MEDIATED REDOX MODULATION OF THE ADAPTIVE IMMUNE RESPONSE By Zhonghua Yan Chair: Ruma Banerjee T cell activation and proliferation requires a reducing microenvironment that is provided by antigen presenting cells especially dendritic cells (DCs). Naturally occurring CD4CD25Foxp3 regulatory T cells (Tregs) suppress proliferation of CD4CD25 effector T cells (Teffs) by mechanisms that are not well understood. Here, we have demonstrated that inhibition by Tregs of DC-induced extracellular redox remodeling is a component of the Treg immunosuppressive mechanism. We showed that the mechanism of redox remodeling during T cell activation involved secretion of glutathione (GSH) by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation resulted in a lower redox potential, which is conducive to proliferation, and changed the net redox status of exofacial protein domains. Suppression of DC-dependent Teff cell proliferation by Tregs was correlated with a significant diminution in extracellular cysteine concentration and was abrogated by addition of exogenous cysteine. We demonstrated that Treg-mediated redox perturbation was antigen-dependent, antigen-" @default.
- W202301088 created "2016-06-24" @default.
- W202301088 creator A5091559614 @default.
- W202301088 date "2010-01-01" @default.
- W202301088 modified "2023-09-22" @default.
- W202301088 title "Thiol-Mediated Redox Modulation of the Adaptive Immune Response." @default.
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