FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023011961> ?p ?o ?g. }

• W2023011961 endingPage "e1003306" @default.
• W2023011961 startingPage "e1003306" @default.
• W2023011961 abstract "Bacterial capsules are common targets for antibody-mediated immunity. The capsule of Bacillus anthracis is unusual among capsules because it is composed of a polymer of poly-γ-d-glutamic acid (γdPGA). We previously generated murine IgG3 monoclonal antibodies (mAbs) to γdPGA that were protective in a murine model of pulmonary anthrax. IgG3 antibodies are characteristic of the murine response to polysaccharide antigens. The goal of the present study was to produce subclass switch variants of the γdPGA mAbs (IgG3→IgG1→IgG2b→IgG2a) and assess the contribution of subclass to antibody affinity and protection. Subclass switch antibodies had identical variable regions but differed in their heavy chains. The results showed that a switch from the protective IgG3 to IgG1, IgG2b or IgG2a was accompanied by i) a loss of protective activity ii) a change in mAb binding to the capsular matrix, and iii) a loss of affinity. These results identify a role for the heavy chain constant region in mAb binding. Hybrid mAbs were constructed in which the CH1, CH2 or CH3 heavy chain constant domains from a non-protective, low binding IgG2b mAb were swapped into the protective IgG3 mAb. The IgG3 mAb that contained the CH1 domain from IgG2b showed no loss of affinity or protection. In contrast, swapping the CH2 or CH3 domains from IgG2b into IgG3 produced a reduction in affinity and a loss of protection. These studies identify a role for the constant region of IgG heavy chains in affinity and protection against an encapsulated bacterial pathogen." @default.
• W2023011961 created "2016-06-24" @default.
• W2023011961 creator A5029573393 @default.
• W2023011961 creator A5035949668 @default.
• W2023011961 creator A5059703162 @default.
• W2023011961 creator A5060110682 @default.
• W2023011961 creator A5060797622 @default.
• W2023011961 creator A5063907853 @default.
• W2023011961 creator A5066797281 @default.
• W2023011961 creator A5082524475 @default.
• W2023011961 creator A5084854753 @default.
• W2023011961 date "2013-04-18" @default.
• W2023011961 modified "2023-10-09" @default.
• W2023011961 title "IgG Subclass and Heavy Chain Domains Contribute to Binding and Protection by mAbs to the Poly γ-D-glutamic Acid Capsular Antigen of Bacillus anthracis" @default.
• W2023011961 cites W1244099196 @default.
• W2023011961 cites W1543704007 @default.
• W2023011961 cites W1548638618 @default.
• W2023011961 cites W1549382023 @default.
• W2023011961 cites W1582658910 @default.
• W2023011961 cites W1587605904 @default.
• W2023011961 cites W1591808469 @default.
• W2023011961 cites W1639090197 @default.
• W2023011961 cites W1765888134 @default.
• W2023011961 cites W1864493807 @default.
• W2023011961 cites W1902971587 @default.
• W2023011961 cites W1965076940 @default.
• W2023011961 cites W1967886843 @default.
• W2023011961 cites W1978052099 @default.
• W2023011961 cites W1979958088 @default.
• W2023011961 cites W1983565271 @default.
• W2023011961 cites W199865532 @default.
• W2023011961 cites W2003809944 @default.
• W2023011961 cites W2010124203 @default.
• W2023011961 cites W2011644834 @default.
• W2023011961 cites W2016708646 @default.
• W2023011961 cites W2031175296 @default.
• W2023011961 cites W2032022102 @default.
• W2023011961 cites W2035922118 @default.
• W2023011961 cites W2041417541 @default.
• W2023011961 cites W2042079029 @default.
• W2023011961 cites W2047582417 @default.
• W2023011961 cites W2057057605 @default.
• W2023011961 cites W2057745345 @default.
• W2023011961 cites W2066241848 @default.
• W2023011961 cites W2068291507 @default.
• W2023011961 cites W2071959434 @default.
• W2023011961 cites W2091537338 @default.
• W2023011961 cites W2105077075 @default.
• W2023011961 cites W2115157794 @default.
• W2023011961 cites W2125571798 @default.
• W2023011961 cites W2142765145 @default.
• W2023011961 cites W2144550157 @default.
• W2023011961 cites W2156913639 @default.
• W2023011961 cites W2160957586 @default.
• W2023011961 cites W2163661597 @default.
• W2023011961 cites W2185335233 @default.
• W2023011961 cites W2312943642 @default.
• W2023011961 cites W4231530219 @default.
• W2023011961 cites W4253958998 @default.
• W2023011961 cites W4313379446 @default.
• W2023011961 doi "https://doi.org/10.1371/journal.ppat.1003306" @default.
• W2023011961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3630167" @default.
• W2023011961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23637599" @default.
• W2023011961 hasPublicationYear "2013" @default.
• W2023011961 type Work @default.
• W2023011961 sameAs 2023011961 @default.
• W2023011961 citedByCount "30" @default.
• W2023011961 countsByYear W20230119612013 @default.
• W2023011961 countsByYear W20230119612014 @default.
• W2023011961 countsByYear W20230119612015 @default.
• W2023011961 countsByYear W20230119612016 @default.
• W2023011961 countsByYear W20230119612017 @default.
• W2023011961 countsByYear W20230119612018 @default.
• W2023011961 countsByYear W20230119612019 @default.
• W2023011961 countsByYear W20230119612020 @default.
• W2023011961 countsByYear W20230119612021 @default.
• W2023011961 countsByYear W20230119612022 @default.
• W2023011961 countsByYear W20230119612023 @default.
• W2023011961 crossrefType "journal-article" @default.
• W2023011961 hasAuthorship W2023011961A5029573393 @default.
• W2023011961 hasAuthorship W2023011961A5035949668 @default.
• W2023011961 hasAuthorship W2023011961A5059703162 @default.
• W2023011961 hasAuthorship W2023011961A5060110682 @default.
• W2023011961 hasAuthorship W2023011961A5060797622 @default.
• W2023011961 hasAuthorship W2023011961A5063907853 @default.
• W2023011961 hasAuthorship W2023011961A5066797281 @default.
• W2023011961 hasAuthorship W2023011961A5082524475 @default.
• W2023011961 hasAuthorship W2023011961A5084854753 @default.
• W2023011961 hasBestOaLocation W20230119611 @default.
• W2023011961 hasConcept C147483822 @default.
• W2023011961 hasConcept C153911025 @default.
• W2023011961 hasConcept C159654299 @default.
• W2023011961 hasConcept C185592680 @default.
• W2023011961 hasConcept C203014093 @default.
• W2023011961 hasConcept C2776194381 @default.
• W2023011961 hasConcept C2780239966 @default.
• W2023011961 hasConcept C523546767 @default.
• W2023011961 hasConcept C542903549 @default.

• next