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• W2023012362 startingPage "186" @default.
• W2023012362 abstract "Synthetic pyrethroids (SPs) are among the most heavily used insecticides for residential and agricultural applications. Their residues have frequently been detected in aquatic ecosystems. Despite their high aquatic toxicity, their toxicokinetics are still unclear. In this study, the kinetics of uptake and depuration of three SPs, permethrin (PM), bifenthrin (BF) and λ-cyhalothrin (λ-CH), were determined for the first time using zebrafish eleutheroembryo assays. The diastereoisomer selectivity of PM in eleutheroembryos was further examined. The results indicated that three SPs were quickly taken up by eleutheroembryos. The bioaccumulation factors of the SPs ranged from 125.4 to 708.4. The depuration of SPs in zebrafish eleutheroembryos followed the first-order process. The elimination rate constants (k2) of SPs in eleutheroembryos ranged from 0.018 h(-1) to 0.0533 h(-1). The half-lives (t1/2) were in the range 13.0-38.5h. The diastereoisomer fraction (DF) values for PM in the eleutheroembryos estimated at different uptake and depuration times were all significantly greater than the original value (DF=0.43), indicating selective enrichment and elimination of cis-PM relative to trans-PM. These results reveal a high capacity for SP bioconcentration by zebrafish eleutheroembryos, suggesting that SPs possess a highly cumulative risk to fish." @default.
• W2023012362 created "2016-06-24" @default.
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• W2023012362 date "2014-09-01" @default.
• W2023012362 modified "2023-09-23" @default.
• W2023012362 title "Dynamics of uptake and elimination of pyrethroid insecticides in zebrafish (Danio rerio) eleutheroembryos" @default.
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• W2023012362 doi "https://doi.org/10.1016/j.ecoenv.2014.05.013" @default.
• W2023012362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24952374" @default.
• W2023012362 hasPublicationYear "2014" @default.
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