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• W2023014790 endingPage "2863" @default.
• W2023014790 startingPage "2859" @default.
• W2023014790 abstract "Herpes simplex virus (HSV) helper functions for (AAV) replication comprise HSV ICP8 and helicase-primase UL5/UL52/UL8. Here we show that N-terminal amino acids of AAV Rep78 that contact the Rep-binding site within the AAV inverted terminal repeat (ITR) are required for ternary-complex formation with infected-cell protein 8 (ICP8) on AAV single-strand DNA (ssDNA) in vitro and for colocalization in nuclear replication domains in vivo. Our data suggest that HSV-dependent AAV replication is initiated by Rep contacting the AAV ITR and by cooperative binding of ICP8 on AAV ssDNA." @default.
• W2023014790 created "2016-06-24" @default.
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• W2023014790 date "2011-12-28" @default.
• W2023014790 modified "2023-10-16" @default.
• W2023014790 title "DNA-Binding Activity of Adeno-Associated Virus Rep Is Required for Inverted Terminal Repeat-Dependent Complex Formation with Herpes Simplex Virus ICP8" @default.
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• W2023014790 doi "https://doi.org/10.1128/jvi.06364-11" @default.
• W2023014790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3302247" @default.
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