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- W2023015362 abstract "Pharmacogenomics is a rapidly developing field of biomedical research, which investigates phenotypic and pharmacodynamic consequences of the genetic variations among individuals. The multi-drug resistance-1, MDR1 (ABCB1) gene belongs to ATP-binding cassette (ABC) family and encodes for membrane transporter P-glycoprotein (P-gp). A wide array of P-gp substrates comprises toxic xenobiotics and numerous commonly used medications including anti-cancer drugs. Under physiological conditions P-gp protects cells against toxins, whereas in malignant cells P-gp confers multi-drug resistance phenotype. Moreover, characteristic tissue localisation enables P-gp to influence the uptake, tissue distribution and elimination of P-gp transported drugs. A number of recent studies identified variety of single nucleotide polymorphisms (SNPs) in the MDR1 gene and demonstrated significant ethnic differences in their allelic frequency distribution. Furthermore, it was shown that some of these SNPs, especially silent C3435T polymorphism in exon 26, may alter P-gp expression and transport activity. Consequently, it is likely that specific functional MDR1 haplotypes may result with altered exposure to toxins and drugs, thus influencing predisposition to certain diseases as well as efficacy or toxicity of pharmacotherapy. In this paper, we focus on the available data concerning the impact of MDR1 polymorphism on the risk and clinical outcome of haematological malignancies. The structure and function of P-gp as well as results of studies addressing the relevance of MDR1 polymorphism in non-haematological disorders are also briefly discussed." @default.
- W2023015362 created "2016-06-24" @default.
- W2023015362 creator A5039661217 @default.
- W2023015362 creator A5069332579 @default.
- W2023015362 date "2004-04-01" @default.
- W2023015362 modified "2023-10-17" @default.
- W2023015362 title "Pharmacogenomics of<i>MDR1</i>/<i>ABCB1</i>Gene: the Influence on Risk and Clinical Outcome of Haematological Malignancies" @default.
- W2023015362 cites W123422070 @default.
- W2023015362 cites W1505376713 @default.
- W2023015362 cites W1565203547 @default.
- W2023015362 cites W1572770561 @default.
- W2023015362 cites W1577781821 @default.
- W2023015362 cites W1779791888 @default.
- W2023015362 cites W1858200607 @default.
- W2023015362 cites W187759550 @default.
- W2023015362 cites W1912531397 @default.
- W2023015362 cites W1960701671 @default.
- W2023015362 cites W1964470226 @default.
- W2023015362 cites W1966858550 @default.
- W2023015362 cites W1967278221 @default.
- W2023015362 cites W1971192013 @default.
- W2023015362 cites W1972856183 @default.
- W2023015362 cites W1975261946 @default.
- W2023015362 cites W1976915106 @default.
- W2023015362 cites W1977235697 @default.
- W2023015362 cites W1977472755 @default.
- W2023015362 cites W1978096998 @default.
- W2023015362 cites W1981301171 @default.
- W2023015362 cites W1981643397 @default.
- W2023015362 cites W1989108550 @default.
- W2023015362 cites W1992309965 @default.
- W2023015362 cites W1998071425 @default.
- W2023015362 cites W1999382644 @default.
- W2023015362 cites W2001312479 @default.
- W2023015362 cites W2002345475 @default.
- W2023015362 cites W2006946734 @default.
- W2023015362 cites W2013047801 @default.
- W2023015362 cites W2013995823 @default.
- W2023015362 cites W2019043185 @default.
- W2023015362 cites W201908734 @default.
- W2023015362 cites W2019909079 @default.
- W2023015362 cites W2024463580 @default.
- W2023015362 cites W2028533496 @default.
- W2023015362 cites W2039288367 @default.
- W2023015362 cites W2039667371 @default.
- W2023015362 cites W2040634965 @default.
- W2023015362 cites W2044894674 @default.
- W2023015362 cites W2046014720 @default.
- W2023015362 cites W2049301565 @default.
- W2023015362 cites W2054458932 @default.
- W2023015362 cites W2056399777 @default.
- W2023015362 cites W2056897801 @default.
- W2023015362 cites W2057755081 @default.
- W2023015362 cites W2060382789 @default.
- W2023015362 cites W2063288921 @default.
- W2023015362 cites W2065456444 @default.
- W2023015362 cites W2066108808 @default.
- W2023015362 cites W2066919313 @default.
- W2023015362 cites W2068865770 @default.
- W2023015362 cites W2082054425 @default.
- W2023015362 cites W2082064626 @default.
- W2023015362 cites W2085577984 @default.
- W2023015362 cites W2086478906 @default.
- W2023015362 cites W2088065273 @default.
- W2023015362 cites W2090841445 @default.
- W2023015362 cites W2091095952 @default.
- W2023015362 cites W2093105834 @default.
- W2023015362 cites W2098142549 @default.
- W2023015362 cites W2098938825 @default.
- W2023015362 cites W2117944128 @default.
- W2023015362 cites W2118342649 @default.
- W2023015362 cites W2126262050 @default.
- W2023015362 cites W2128940717 @default.
- W2023015362 cites W2130021614 @default.
- W2023015362 cites W2138891742 @default.
- W2023015362 cites W2149320251 @default.
- W2023015362 cites W2153591132 @default.
- W2023015362 cites W2155033804 @default.
- W2023015362 cites W2159880660 @default.
- W2023015362 cites W2165521873 @default.
- W2023015362 cites W2166153381 @default.
- W2023015362 cites W2171279314 @default.
- W2023015362 cites W2271456353 @default.
- W2023015362 cites W2280630460 @default.
- W2023015362 cites W2316641359 @default.
- W2023015362 cites W2316715165 @default.
- W2023015362 cites W2319249430 @default.
- W2023015362 cites W2330149118 @default.
- W2023015362 cites W250950884 @default.
- W2023015362 cites W2764775166 @default.
- W2023015362 cites W321996270 @default.
- W2023015362 cites W4235607015 @default.
- W2023015362 cites W4249152566 @default.
- W2023015362 cites W47219713 @default.
- W2023015362 cites W509271 @default.
- W2023015362 doi "https://doi.org/10.1080/10245330310001638974" @default.
- W2023015362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15203864" @default.
- W2023015362 hasPublicationYear "2004" @default.