FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023016635> ?p ?o ?g. }

• W2023016635 endingPage "300" @default.
• W2023016635 startingPage "292" @default.
• W2023016635 abstract "The frequency of point mutations in p53 (exons 4–7) and in Ki-ras, Ha-ras, and N-ras (exons 1 and 2) and the expression of p53 protein were evaluated in the liver tumors of Wistar rats of a 104-week carcinogenicity study on 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a chlorine disinfection by-product in drinking water. Mutations were analyzed in 16 hepatocellular adenomas, 7 hepatocellular carcinomas, 23 cholangiomas, and 2 cholangiocarcinomas of the MX-treated animals and one hepatocellular carcinoma and cholangiocarcinoma in control animals using PCR–SSCP (polymerase chain reaction–single-strand conformation polymorphism) or PCR–TGGE (temperature gradient gel electrophoresis) and direct sequencing. The expression of the p53 protein (wild-type and mutated protein) was detected by immunohistochemistry (CM5 antibody). The expression of p53 and that of the proliferating cell nuclear antigen (PCNA, 19 A2) were also evaluated in livers of female animals exposed to MX for 1 week, 3 weeks, or 18 weeks. Altogether, four mutations were found in p53 in three tumors, in two hepatocellular adenomas, and one cholangiocarcinoma, all in females receiving the highest MX dose (6.6 mg/kg/day) of the study. Three of the mutations were G:C → A:T transitions and one was an A:T → T:A transversion. The mutations were scattered at different codons and positions of the codon. One hepatocellular adenoma contained two p53 mutations. All cholangiomas and cholangiocarcinomas, but no hepatocellular adenomas and carcinomas, overexpressed the p53 protein. MX treatment did not induce p53 expression at any age in the liver or alter the expression of the PCNA in the liver of younger animals. The p53 protein was overexpressed in hyperplastic bile ducts in aged rats but not in bile ducts of younger rats (up to 24 weeks). No mutations were observed in either Ki-ras, Ha-ras, or N-ras of the liver tumors. These data suggest that point mutations in p53, Ki-ras, Ha-ras, and N-ras are not involved in the MX-induced liver carcinogenesis in rats. Environ. Mol. Mutagen. 36:292–300, 2000 © 2000 Wiley-Liss, Inc." @default.
• W2023016635 created "2016-06-24" @default.
• W2023016635 creator A5014891832 @default.
• W2023016635 creator A5016045878 @default.
• W2023016635 creator A5019502485 @default.
• W2023016635 creator A5058191124 @default.
• W2023016635 creator A5066441042 @default.
• W2023016635 creator A5072999390 @default.
• W2023016635 creator A5091348167 @default.
• W2023016635 date "2000-01-01" @default.
• W2023016635 modified "2023-10-17" @default.
• W2023016635 title "No consistent pattern of mutations inp53 andras genes in liver tumors of rat treated with the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)" @default.
• W2023016635 cites W1545696391 @default.
• W2023016635 cites W1963985392 @default.
• W2023016635 cites W1972695454 @default.
• W2023016635 cites W1974739149 @default.
• W2023016635 cites W1975507786 @default.
• W2023016635 cites W1979484087 @default.
• W2023016635 cites W1981999339 @default.
• W2023016635 cites W1987579426 @default.
• W2023016635 cites W1992113844 @default.
• W2023016635 cites W1995369818 @default.
• W2023016635 cites W2000293224 @default.
• W2023016635 cites W2004730613 @default.
• W2023016635 cites W2008151171 @default.
• W2023016635 cites W2011869626 @default.
• W2023016635 cites W2014572837 @default.
• W2023016635 cites W2015663834 @default.
• W2023016635 cites W2029924301 @default.
• W2023016635 cites W2030650515 @default.
• W2023016635 cites W2033797913 @default.
• W2023016635 cites W2037502174 @default.
• W2023016635 cites W2037670899 @default.
• W2023016635 cites W2049296953 @default.
• W2023016635 cites W2052331208 @default.
• W2023016635 cites W2063875790 @default.
• W2023016635 cites W2065925808 @default.
• W2023016635 cites W2070484449 @default.
• W2023016635 cites W2072899483 @default.
• W2023016635 cites W2080388028 @default.
• W2023016635 cites W2084261443 @default.
• W2023016635 cites W2088392807 @default.
• W2023016635 cites W2089720218 @default.
• W2023016635 cites W2091534000 @default.
• W2023016635 cites W2093269827 @default.
• W2023016635 cites W2095302244 @default.
• W2023016635 cites W2096841880 @default.
• W2023016635 cites W2099942653 @default.
• W2023016635 cites W2101237386 @default.
• W2023016635 cites W2101263910 @default.
• W2023016635 cites W2103170384 @default.
• W2023016635 cites W2105620485 @default.
• W2023016635 cites W2106740562 @default.
• W2023016635 cites W2114590280 @default.
• W2023016635 cites W2136835420 @default.
• W2023016635 cites W2152665713 @default.
• W2023016635 cites W2153599383 @default.
• W2023016635 cites W2155368714 @default.
• W2023016635 cites W2330325244 @default.
• W2023016635 cites W4302405763 @default.
• W2023016635 cites W94325575 @default.
• W2023016635 doi "https://doi.org/10.1002/1098-2280(2000)36:4<292::aid-em5>3.0.co;2-3" @default.
• W2023016635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11152562" @default.
• W2023016635 hasPublicationYear "2000" @default.
• W2023016635 type Work @default.
• W2023016635 sameAs 2023016635 @default.
• W2023016635 citedByCount "11" @default.
• W2023016635 crossrefType "journal-article" @default.
• W2023016635 hasAuthorship W2023016635A5014891832 @default.
• W2023016635 hasAuthorship W2023016635A5016045878 @default.
• W2023016635 hasAuthorship W2023016635A5019502485 @default.
• W2023016635 hasAuthorship W2023016635A5058191124 @default.
• W2023016635 hasAuthorship W2023016635A5066441042 @default.
• W2023016635 hasAuthorship W2023016635A5072999390 @default.
• W2023016635 hasAuthorship W2023016635A5091348167 @default.
• W2023016635 hasBestOaLocation W20230166351 @default.
• W2023016635 hasConcept C104317684 @default.
• W2023016635 hasConcept C114246631 @default.
• W2023016635 hasConcept C129219603 @default.
• W2023016635 hasConcept C153911025 @default.
• W2023016635 hasConcept C176944494 @default.
• W2023016635 hasConcept C203014093 @default.
• W2023016635 hasConcept C204232928 @default.
• W2023016635 hasConcept C2776639595 @default.
• W2023016635 hasConcept C2777428134 @default.
• W2023016635 hasConcept C2778019345 @default.
• W2023016635 hasConcept C2778141868 @default.
• W2023016635 hasConcept C34688535 @default.
• W2023016635 hasConcept C36823959 @default.
• W2023016635 hasConcept C501734568 @default.
• W2023016635 hasConcept C502942594 @default.
• W2023016635 hasConcept C54355233 @default.
• W2023016635 hasConcept C64872895 @default.
• W2023016635 hasConcept C86803240 @default.
• W2023016635 hasConceptScore W2023016635C104317684 @default.
• W2023016635 hasConceptScore W2023016635C114246631 @default.
• W2023016635 hasConceptScore W2023016635C129219603 @default.
• W2023016635 hasConceptScore W2023016635C153911025 @default.

• next