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- W2023016929 abstract "The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target of FOXP3 repression, but that FOXP3 also induces two miRs, miR-7 and miR-155, which specifically target the 3′-UTR of SATB1 to further regulate its expression. We conclude that FOXP3-regulated miRs form part of the mechanism by which FOXP3 prevents the transformation of the healthy breast epithelium to a cancerous phenotype. Approaches aimed at restoring FOXP3 function and the miRs it regulates could help provide new approaches to target breast cancer." @default.
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- W2023016929 date "2011-07-11" @default.
- W2023016929 modified "2023-10-01" @default.
- W2023016929 title "FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells" @default.
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- W2023016929 doi "https://doi.org/10.1038/onc.2011.293" @default.
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