FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023018045> ?p ?o ?g. }

• W2023018045 endingPage "764" @default.
• W2023018045 startingPage "755" @default.
• W2023018045 abstract "The level of expression of somatostatin messenger RNA-containing neurons in human brain was visualized and quantified by in situ hybridization with a 35S-labelled oligonucleotide complementary to amino acids 96–111 of the preprosomatostatin complementary DNA sequence. The analysis was carried out in the frontal and parahippocampal cortices and hippocampus of six age- and post mortem delay-matched Alzheimer's disease and control brains. By northern blot analysis, in frontal cortex samples, 18S rRNA degradation was identical in control and Alzheimer brains and somatostatin messenger RNAs migrated as a single band of 1 kb. By in situ hybridization, specificity was demonstrated by abolition of the signal using either an excess of unlabelled antisense probe or using a labelled sense probe. Somatostatin messenger RNA-containing neurons displayed a similar regional and subregional distribution in control subjects and patients with Alzheimer's disease, being more abundant in the frontal cortex, followed by the hippocampus and the parahippocampal cortex. An overall reduction of labelled cell density was observed in patients with Alzheimer's disease (frontal cortex gray matter: −41%; white matter: −66%; hippocampus: −44%; parahippocampal cortex white matter: −40%). Due to a great variation between brains, this decrease only reached significance in the parahippocampal cortex ( − 59%, P<0.05). A significantly lower level of expression of somatostatin messenger RNA per somatostatinergic cell was observed in the hippocampus of Alzheimer's disease patients ( − 47%, P < 0.05), but not in frontal cortex gray (−17%) and white (−36%) matter and parahippocampal cortex gray (−42%) and white ( − 29%) matter. These data are in accordance with the distribution of somatostatin cells as visualized by immunohis-tochemistry in human brain. They indicate that the ability of cortical cells to express somatostatin messenger RNA is partially preserved in Alzheimer disease brains and that the decrease in the amount of somatostatin messenger RNA per cell is restricted to the hippocampal formation." @default.
• W2023018045 created "2016-06-24" @default.
• W2023018045 creator A5031611475 @default.
• W2023018045 creator A5043770262 @default.
• W2023018045 creator A5049773728 @default.
• W2023018045 creator A5067769815 @default.
• W2023018045 creator A5070037872 @default.
• W2023018045 creator A5079627372 @default.
• W2023018045 creator A5089989719 @default.
• W2023018045 date "1994-08-01" @default.
• W2023018045 modified "2023-09-25" @default.
• W2023018045 title "Somatostatin messenger rna-containing neurons in Alzheimer's disease: An in situ hybridization study in hippocampus, parahippocampal cortex and frontal cortex" @default.
• W2023018045 cites W1597868762 @default.
• W2023018045 cites W1968909132 @default.
• W2023018045 cites W1969455604 @default.
• W2023018045 cites W1971044713 @default.
• W2023018045 cites W1979864353 @default.
• W2023018045 cites W1982505761 @default.
• W2023018045 cites W1991185591 @default.
• W2023018045 cites W1992274255 @default.
• W2023018045 cites W1996067981 @default.
• W2023018045 cites W2010938575 @default.
• W2023018045 cites W2023075180 @default.
• W2023018045 cites W2037047980 @default.
• W2023018045 cites W2052742260 @default.
• W2023018045 cites W2053400270 @default.
• W2023018045 cites W2053701788 @default.
• W2023018045 cites W2065128301 @default.
• W2023018045 cites W2069771865 @default.
• W2023018045 cites W2076672023 @default.
• W2023018045 cites W2091492013 @default.
• W2023018045 cites W2113861132 @default.
• W2023018045 cites W2156220037 @default.
• W2023018045 doi "https://doi.org/10.1016/0306-4522(94)90399-9" @default.
• W2023018045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7838375" @default.
• W2023018045 hasPublicationYear "1994" @default.
• W2023018045 type Work @default.
• W2023018045 sameAs 2023018045 @default.
• W2023018045 citedByCount "47" @default.
• W2023018045 countsByYear W20230180452012 @default.
• W2023018045 countsByYear W20230180452013 @default.
• W2023018045 countsByYear W20230180452014 @default.
• W2023018045 countsByYear W20230180452015 @default.
• W2023018045 countsByYear W20230180452017 @default.
• W2023018045 countsByYear W20230180452018 @default.
• W2023018045 countsByYear W20230180452022 @default.
• W2023018045 crossrefType "journal-article" @default.
• W2023018045 hasAuthorship W2023018045A5031611475 @default.
• W2023018045 hasAuthorship W2023018045A5043770262 @default.
• W2023018045 hasAuthorship W2023018045A5049773728 @default.
• W2023018045 hasAuthorship W2023018045A5067769815 @default.
• W2023018045 hasAuthorship W2023018045A5070037872 @default.
• W2023018045 hasAuthorship W2023018045A5079627372 @default.
• W2023018045 hasAuthorship W2023018045A5089989719 @default.
• W2023018045 hasConcept C104317684 @default.
• W2023018045 hasConcept C105580179 @default.
• W2023018045 hasConcept C126322002 @default.
• W2023018045 hasConcept C126838900 @default.
• W2023018045 hasConcept C134018914 @default.
• W2023018045 hasConcept C143409427 @default.
• W2023018045 hasConcept C169760540 @default.
• W2023018045 hasConcept C2776297358 @default.
• W2023018045 hasConcept C2777348757 @default.
• W2023018045 hasConcept C2778048536 @default.
• W2023018045 hasConcept C2778186239 @default.
• W2023018045 hasConcept C2781041448 @default.
• W2023018045 hasConcept C2781099131 @default.
• W2023018045 hasConcept C2781161787 @default.
• W2023018045 hasConcept C2781192897 @default.
• W2023018045 hasConcept C2993858690 @default.
• W2023018045 hasConcept C55493867 @default.
• W2023018045 hasConcept C71924100 @default.
• W2023018045 hasConcept C81439078 @default.
• W2023018045 hasConcept C86803240 @default.
• W2023018045 hasConceptScore W2023018045C104317684 @default.
• W2023018045 hasConceptScore W2023018045C105580179 @default.
• W2023018045 hasConceptScore W2023018045C126322002 @default.
• W2023018045 hasConceptScore W2023018045C126838900 @default.
• W2023018045 hasConceptScore W2023018045C134018914 @default.
• W2023018045 hasConceptScore W2023018045C143409427 @default.
• W2023018045 hasConceptScore W2023018045C169760540 @default.
• W2023018045 hasConceptScore W2023018045C2776297358 @default.
• W2023018045 hasConceptScore W2023018045C2777348757 @default.
• W2023018045 hasConceptScore W2023018045C2778048536 @default.
• W2023018045 hasConceptScore W2023018045C2778186239 @default.
• W2023018045 hasConceptScore W2023018045C2781041448 @default.
• W2023018045 hasConceptScore W2023018045C2781099131 @default.
• W2023018045 hasConceptScore W2023018045C2781161787 @default.
• W2023018045 hasConceptScore W2023018045C2781192897 @default.
• W2023018045 hasConceptScore W2023018045C2993858690 @default.
• W2023018045 hasConceptScore W2023018045C55493867 @default.
• W2023018045 hasConceptScore W2023018045C71924100 @default.
• W2023018045 hasConceptScore W2023018045C81439078 @default.
• W2023018045 hasConceptScore W2023018045C86803240 @default.
• W2023018045 hasIssue "4" @default.
• W2023018045 hasLocation W20230180451 @default.
• W2023018045 hasLocation W20230180452 @default.
• W2023018045 hasOpenAccess W2023018045 @default.

• next