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- W2023018666 abstract "A recessive temperature sensitive mutant has been Isolated that Is defective in ribosomal RNA processing. By Northern analysis, this mutant was found to accumulate three novel rRNA species: 23S′, 18S′ and 7S′, each of which contains sequences from the spacer region between 25S and 18S rRNA. 35S pre-rRNA accumulates, while the level of the 20S and 27S rRNA processing intermediates is depressed. Pulse-chase analysis demonstrates that the processing of 35S prerRNA is slowed. The defect in the mutant appears to be at the first processing step, which generates 20S and 27S rRNA. 7S′ RNA is a form of 5.8S RNA whose 5′ end is extended by 149 nucleotides to a position just 5 nucleotides downstream of the normal cleavage site that produces 20S and 27S rRNA. 7S′ RNA can assemble into 60S ribosomal subunits, but such subunits are relatively ineffective in joining polyribosomes. A single lesion is responsible for the pre-rRNA processing defect and the temperature sensitivity. The affected gene is designated RRP2." @default.
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- W2023018666 date "1991-01-01" @default.
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- W2023018666 title "A temperature sensitive mutant of<i>Saccharomyces cerevisiae</i>defective in pre-rRNA processing" @default.
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- W2023018666 doi "https://doi.org/10.1093/nar/19.18.5059" @default.
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