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• W2023019056 abstract "To assess the effect of prostacyclin on the diseased coronary circulation basally and, in particular, on the coronary responses to the cold pressor test, a small dose of 4 ng/kg/min and a large dose of 8 to 10 ng/kg/min was infused in 11 patients with stable angina pectoris. Coronary blood flow was measured by coronary sinus thermodilution technique. The mean blood pressure decreased from 97 ± 5 to 89 ± 5 mm Hg during the low-dose infusion (p <0.005) and to 81 ± 5 mm Hg during the high-dose infusion (p <0.001); the heart rate increased from 65 ± 4 to 69 ± 4 beats/min during the low-dose infusion (p < 0.05) and to 78 ± 5 beats/min during the highdose infusion (p < 0.001). Systemic vascular resistance decreased by 11 ± 4% with small doses (p < 0.05) and by 38 ± 4% with large doses (p < 0.001) of prostacyclin, and coronary vascular resistance decreased by 16 ± 7% (p < 0.05) with the small dose and by 29 ± 6% (p < 0.001) with the large dose of prostacyclin. Seven of 11 patients showed a baseline vasoconstrictor response to the cold pressor test (increase in coronary vascular resistance of 11 ± 2%). This increase in coronary vascular resistance was not altered by either the small or the large dose of prostacyclin. Thus, prostacyclin causes marked coronary and systemic vasodilation, with no evidence of selective enhancement of the sensitivity of the diseased coronary circulation. Although the absolute coronary vascular resistance decreases, the vasoconstrictor response to the cold pressor test is not blocked by prostacyclin. Prostacyclin has a narrow therapeutic range limited by hypotension and tachycardia. Nevertheless, the unique combined vasodilator and platelet antiaggregatory properties of prostacyclin suggest that it should be investigated further for use in acute ischemic events." @default.
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• W2023019056 date "1984-06-01" @default.
• W2023019056 modified "2023-09-27" @default.
• W2023019056 title "Effects of prostacyclin on coronary hemodynamics at rest and in response to cold pressor testing in patients with angina pectoris" @default.
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• W2023019056 doi "https://doi.org/10.1016/0002-9149(84)90567-8" @default.
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